Hampson P - Search Results

1

The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner.

Hampson P, Kavanagh D, Smith E, Wang K, Lord JM, Ed Rainger G. Hampson P, et al. Cancer Immunol Immunother. 2008 Aug;57(8):1241-51. doi: 10.1007/s00262-008-0458-9. Epub 2008 Feb 12. Cancer Immunol Immunother. 2008. PMID: 18265980 Free PMC article.

2

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK, Bunce CM, Lord JM. Hampson P, et al. Blood. 2005 Aug 15;106(4):1362-8. doi: 10.1182/blood-2004-10-4117. Epub 2005 Apr 21. Blood. 2005. PMID: 15845901 Free article.

3

Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).

Hampson P, Wang K, Milverton L, Ersvaer E, Bruserud O, Lord JM. Hampson P, et al. Apoptosis. 2010 Aug;15(8):946-55. doi: 10.1007/s10495-010-0507-7. Apoptosis. 2010. PMID: 20467815

4

Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.

Challacombe JM, Suhrbier A, Parsons PG, Jones B, Hampson P, Kavanagh D, Rainger GE, Morris M, Lord JM, Le TT, Hoang-Le D, Ogbourne SM. Challacombe JM, et al. Among authors: hampson p. J Immunol. 2006 Dec 1;177(11):8123-32. doi: 10.4049/jimmunol.177.11.8123. J Immunol. 2006. PMID: 17114487

5

T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005.

Ersvaer E, Hampson P, Hatfield K, Ulvestad E, Wendelbo Ø, Lord JM, Gjertsen BT, Bruserud Ø. Ersvaer E, et al. Among authors: hampson p. Cancer Immunol Immunother. 2007 Jun;56(6):913-25. doi: 10.1007/s00262-006-0236-5. Epub 2006 Nov 8. Cancer Immunol Immunother. 2007. PMID: 17115221 Free PMC article.

6

Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta.

Lee WY, Hampson P, Coulthard L, Ali F, Salmon M, Lord JM, Scheel-Toellner D. Lee WY, et al. Among authors: hampson p. J Biol Chem. 2010 Jul 30;285(31):23889-98. doi: 10.1074/jbc.M109.041962. Epub 2010 May 14. J Biol Chem. 2010. PMID: 20472553 Free PMC article.

7

Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events.

Francis N, Wong SH, Hampson P, Wang K, Young SP, Deigner HP, Salmon M, Scheel-Toellner D, Lord JM. Francis N, et al. Among authors: hampson p. Biochim Biophys Acta. 2011 Oct;1813(10):1822-6. doi: 10.1016/j.bbamcr.2011.07.004. Epub 2011 Jul 19. Biochim Biophys Acta. 2011. PMID: 21781990 Free article.

8

Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease.

Hampson P, Hazeldine J, Lord JM. Hampson P, et al. Curr Opin Hematol. 2013 Jan;20(1):10-5. doi: 10.1097/MOH.0b013e32835b06be. Curr Opin Hematol. 2013. PMID: 23196895 Review.

9

Proceedings of the First International Conference on PEP005.

Ogbourne SM, Hampson P, Lord JM, Parsons P, De Witte PA, Suhrbier A. Ogbourne SM, et al. Among authors: hampson p. Anticancer Drugs. 2007 Mar;18(3):357-62. doi: 10.1097/CAD.0b013e3280149ec5. Anticancer Drugs. 2007. PMID: 17264770

10

The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.

Ersvaer E, Kittang AO, Hampson P, Sand K, Gjertsen BT, Lord JM, Bruserud O. Ersvaer E, et al. Among authors: hampson p. Toxins (Basel). 2010 Jan;2(1):174-94. doi: 10.3390/toxins2010174. Epub 2010 Jan 22. Toxins (Basel). 2010. PMID: 22069553 Free PMC article.

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