Wang YP - Search Results

1

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Wang YP, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3887-94. doi: 10.1016/j.bmc.2008.01.039. Epub 2008 Jan 30. Bioorg Med Chem. 2008. PMID: 18267363

2

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.

He Y, Chen F, Sun G, Wang Y, De Clercq E, Balzarini J, Pannecouque C. He Y, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3173-6. doi: 10.1016/j.bmcl.2004.04.008. Bioorg Med Chem Lett. 2004. PMID: 15149669

3

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.

He Y, Chen F, Yu X, Wang Y, De Clercq E, Balzarini J, Pannecouque C. He Y, et al. Bioorg Chem. 2004 Dec;32(6):536-48. doi: 10.1016/j.bioorg.2004.05.007. Bioorg Chem. 2004. PMID: 15530994

4

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.

Sun GF, Chen XX, Chen FE, Wang YP, De Clercq E, Balzarini J, Pannecouque C. Sun GF, et al. Among authors: wang yp. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):886-92. doi: 10.1248/cpb.53.886. Chem Pharm Bull (Tokyo). 2005. PMID: 16079514 Free article.

5

Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues.

Wang Y, Chen FE, Balzarini J, De Clercq E, Pannecouque C. Wang Y, et al. Chem Biodivers. 2008 Jan;5(1):168-76. doi: 10.1002/cbdv.200890008. Chem Biodivers. 2008. PMID: 18205120

6

Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.

Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Wang YP, et al. Eur J Med Chem. 2009 Mar;44(3):1016-23. doi: 10.1016/j.ejmech.2008.06.028. Epub 2008 Jul 4. Eur J Med Chem. 2009. PMID: 18692274

7

C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity.

Rui RM, Tang CR, Zhang CT, Pan WK, Gan K, Luo RH, Wei ZQ, Jing FS, Huang SM, Yang LM, Li YM, Wang YP, Xiao WL, Zhang HB, Zheng YT, He YP. Rui RM, et al. Among authors: wang yp. Bioorg Chem. 2022 Feb;119:105494. doi: 10.1016/j.bioorg.2021.105494. Epub 2021 Nov 19. Bioorg Chem. 2022. PMID: 34836643

8

Synthesis and anti-HIV activity of non-nucleoside reverse-transcriptase inhibitor DB02 phosphate derivatives based on water-soluble optimization.

Wang JB, Ma MD, Lu N, Yang YZ, Yang JX, Li YM, Xie CQ, Ma NY, Luo RH, Wang YP, Yang LM, Zhang HB, Zheng YT, He YP. Wang JB, et al. Among authors: wang yp. Drug Dev Res. 2023 May;84(3):423-432. doi: 10.1002/ddr.22036. Epub 2023 Feb 8. Drug Dev Res. 2023. PMID: 36751971

9

Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors.

Wu Y, Tang C, Rui R, Yang L, Ding W, Wang J, Li Y, Lai CC, Wang Y, Luo R, Xiao W, Zhang H, Zheng Y, He Y. Wu Y, et al. Acta Pharm Sin B. 2020 Mar;10(3):512-528. doi: 10.1016/j.apsb.2019.08.009. Epub 2019 Sep 5. Acta Pharm Sin B. 2020. PMID: 32140396 Free PMC article.

10

DB-02, a C-6-cyclohexylmethyl substituted pyrimidinone HIV-1 reverse transcriptase inhibitor with nanomolar activity, displays an improved sensitivity against K103N or Y181C than S-DABOs.

Zhang XJ, Lu LH, Wang RR, Wang YP, Luo RH, Cong Lai C, Yang LM, He YP, Zheng YT. Zhang XJ, et al. Among authors: wang rr, wang yp. PLoS One. 2013 Nov 25;8(11):e81489. doi: 10.1371/journal.pone.0081489. eCollection 2013. PLoS One. 2013. PMID: 24282600 Free PMC article.

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