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Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.
Ishihara T, Seki N, Hirayama F, Orita M, Koshio H, Taniuchi Y, Sakai-Moritani Y, Iwatsuki Y, Kaku S, Kawasaki T, Matsumoto Y, Tsukamoto S. Ishihara T, et al. Among authors: orita m. Bioorg Med Chem. 2007 Jun 15;15(12):4175-92. doi: 10.1016/j.bmc.2007.03.066. Epub 2007 Mar 25. Bioorg Med Chem. 2007. PMID: 17416533
Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.
Nagashima S, Nagata H, Iwata M, Yokota M, Moritomo H, Orita M, Kuromitsu S, Koakutsu A, Ohga K, Takeuchi M, Ohta M, Tsukamoto S. Nagashima S, et al. Among authors: orita m. Bioorg Med Chem. 2008 Jul 1;16(13):6509-21. doi: 10.1016/j.bmc.2008.05.031. Epub 2008 May 17. Bioorg Med Chem. 2008. PMID: 18534856
Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.
Onda K, Shiraki R, Ogiyama T, Yokoyama K, Momose K, Katayama N, Orita M, Yamaguchi T, Furutani M, Hamada N, Takeuchi M, Okada M, Ohta M, Tsukamoto S. Onda K, et al. Among authors: orita m. Bioorg Med Chem. 2008 Dec 1;16(23):10001-12. doi: 10.1016/j.bmc.2008.10.021. Epub 2008 Oct 12. Bioorg Med Chem. 2008. PMID: 18952447
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
Hattori K, Orita M, Toda S, Imanishi M, Itou S, Nakajima Y, Tanabe D, Washizuka K, Araki T, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F. Hattori K, et al. Among authors: orita m. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4679-83. doi: 10.1016/j.bmcl.2009.06.083. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19608416
191 results