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Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma.
Ochkur SI, Jacobsen EA, Protheroe CA, Biechele TL, Pero RS, McGarry MP, Wang H, O'Neill KR, Colbert DC, Colby TV, Shen H, Blackburn MR, Irvin CC, Lee JJ, Lee NA. Ochkur SI, et al. Among authors: protheroe ca. J Immunol. 2007 Jun 15;178(12):7879-89. doi: 10.4049/jimmunol.178.12.7879. J Immunol. 2007. PMID: 17548626
Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation.
Ochkur SI, Doyle AD, Jacobsen EA, LeSuer WE, Li W, Protheroe CA, Zellner KR, Colbert D, Shen HH, Irvin CG, Lee JJ, Lee NA. Ochkur SI, et al. Among authors: protheroe ca. J Leukoc Biol. 2017 Sep;102(3):589-599. doi: 10.1189/jlb.3HI1116-488RR. Epub 2017 May 17. J Leukoc Biol. 2017. PMID: 28515227 Free PMC article.
Defining a link with asthma in mice congenitally deficient in eosinophils.
Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, Lenkiewicz E, Colbert D, Rinaldi L, Ackerman SJ, Irvin CG, Lee NA. Lee JJ, et al. Science. 2004 Sep 17;305(5691):1773-6. doi: 10.1126/science.1099472. Science. 2004. PMID: 15375267
29 results