Lakey RL - Search Results

1

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.

Litherland GJ, Dixon C, Lakey RL, Robson T, Jones D, Young DA, Cawston TE, Rowan AD. Litherland GJ, et al. Among authors: lakey rl. J Biol Chem. 2008 May 23;283(21):14221-9. doi: 10.1074/jbc.M710136200. Epub 2008 Mar 10. J Biol Chem. 2008. PMID: 18332138 Free article.

2

Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.

Lakey RL, Cawston TE. Lakey RL, et al. Rheumatology (Oxford). 2009 Oct;48(10):1208-12. doi: 10.1093/rheumatology/kep236. Epub 2009 Aug 18. Rheumatology (Oxford). 2009. PMID: 19690126

3

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. Barter MJ, et al. Among authors: lakey rl. Ann Rheum Dis. 2010 Dec;69(12):2189-98. doi: 10.1136/ard.2010.129197. Epub 2010 Aug 6. Ann Rheum Dis. 2010. PMID: 20693272

4

Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.

Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD. Barksby HE, et al. Arthritis Rheum. 2006 Oct;54(10):3244-53. doi: 10.1002/art.22167. Arthritis Rheum. 2006. PMID: 17009259 Free article.

5

A novel paradigm for dendritic cells as effectors of cartilage destruction.

Lakey RL, Morgan TG, Rowan AD, Isaacs JD, Cawston TE, Hilkens CM. Lakey RL, et al. Rheumatology (Oxford). 2009 May;48(5):502-7. doi: 10.1093/rheumatology/kep040. Epub 2009 Mar 5. Rheumatology (Oxford). 2009. PMID: 19269957

6

Assay of matrix metalloproteinases against matrix substrates.

Cawston TE, Lakey RL, Rowan AD. Cawston TE, et al. Among authors: lakey rl. Methods Mol Biol. 2010;622:245-55. doi: 10.1007/978-1-60327-299-5_15. Methods Mol Biol. 2010. PMID: 20135287

7

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.

Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM. Young DA, et al. Among authors: lakey rl. Arthritis Res Ther. 2005;7(3):R503-12. doi: 10.1186/ar1702. Epub 2005 Feb 22. Arthritis Res Ther. 2005. PMID: 15899037 Free PMC article.

8

Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines.

Sukkar TZ, Thomason JM, Cawston TE, Lakey R, Jones D, Catterall J, Seymour RA. Sukkar TZ, et al. J Periodontal Res. 2007 Dec;42(6):580-8. doi: 10.1111/j.1600-0765.2007.00986.x. J Periodontal Res. 2007. PMID: 17956473

9

Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up.

Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, Young-Min S, Isaacs JD. Houseman M, et al. Arthritis Res Ther. 2012 Feb 7;14(1):R30. doi: 10.1186/ar3734. Arthritis Res Ther. 2012. PMID: 22314025 Free PMC article.

10

Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings.

Myers A, Lakey R, Cawston TE, Kay LJ, Walker DJ. Myers A, et al. Rheumatology (Oxford). 2004 Mar;43(3):272-6. doi: 10.1093/rheumatology/keh032. Epub 2003 Oct 1. Rheumatology (Oxford). 2004. PMID: 14523226

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