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The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line.
Hanifi-Moghaddam P, Sijmons B, Ott MC, van Ijcken WF, Nowzari D, Kuhne EC, van der Spek P, Kloosterboer HJ, Burger CW, Blok LJ. Hanifi-Moghaddam P, et al. Among authors: van ijcken wf, van der spek p. J Mol Endocrinol. 2006 Dec;37(3):405-13. doi: 10.1677/jme.1.02057. J Mol Endocrinol. 2006. PMID: 17170081
Difference in signalling between various hormone therapies in endometrium, myometrium and upper part of the vagina.
Hanifi-Moghaddam P, Boers-Sijmons B, Klaassens AH, van Wijk FH, Van Ijcken WF, Van der Spek P, Verheul HA, Kloosterboer HJ, Burger CW, Blok LJ. Hanifi-Moghaddam P, et al. Among authors: van wijk fh, van ijcken wf, van der spek p. Hum Reprod. 2008 Feb;23(2):298-305. doi: 10.1093/humrep/dem366. Epub 2007 Dec 11. Hum Reprod. 2008. PMID: 18077316 Clinical Trial.
Physiological thyroid hormone levels regulate numerous skeletal muscle transcripts.
Visser WE, Heemstra KA, Swagemakers SM, Ozgür Z, Corssmit EP, Burggraaf J, van Ijcken WF, van der Spek PJ, Smit JW, Visser TJ. Visser WE, et al. Among authors: van der spek pj, van ijcken wf. J Clin Endocrinol Metab. 2009 Sep;94(9):3487-96. doi: 10.1210/jc.2009-0782. Epub 2009 Jun 30. J Clin Endocrinol Metab. 2009. PMID: 19567520
Gene expression-based classification of non-small cell lung carcinomas and survival prediction.
Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, Grosveld F, Philipsen S. Hou J, et al. Among authors: van der leest c, van ijcken w, van der spek p. PLoS One. 2010 Apr 22;5(4):e10312. doi: 10.1371/journal.pone.0010312. PLoS One. 2010. PMID: 20421987 Free PMC article.
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.
Borg J, Papadopoulos P, Georgitsi M, Gutiérrez L, Grech G, Fanis P, Phylactides M, Verkerk AJ, van der Spek PJ, Scerri CA, Cassar W, Galdies R, van Ijcken W, Ozgür Z, Gillemans N, Hou J, Bugeja M, Grosveld FG, von Lindern M, Felice AE, Patrinos GP, Philipsen S. Borg J, et al. Among authors: van der spek pj, van ijcken w. Nat Genet. 2010 Sep;42(9):801-5. doi: 10.1038/ng.630. Epub 2010 Aug 1. Nat Genet. 2010. PMID: 20676099 Free PMC article.
Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.
Nagel JH, Peeters JK, Smid M, Sieuwerts AM, Wasielewski M, de Weerd V, Trapman-Jansen AM, van den Ouweland A, Brüggenwirth H, van I Jcken WF, Klijn JG, van der Spek PJ, Foekens JA, Martens JW, Schutte M, Meijers-Heijboer H. Nagel JH, et al. Breast Cancer Res Treat. 2012 Apr;132(2):439-48. doi: 10.1007/s10549-011-1588-x. Epub 2011 May 26. Breast Cancer Res Treat. 2012. PMID: 21614566
285 results