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Phenylarsine oxide (PAO) more intensely induces apoptosis in acute promyelocytic leukemia and As2O3-resistant APL cell lines than As2O3 by activating the mitochondrial pathway.
Sahara N, Takeshita A, Kobayashi M, Shigeno K, Nakamura S, Shinjo K, Naito K, Maekawa M, Horii T, Ohnishi K, Kitamura K, Naoe T, Hayash H, Ohno R. Sahara N, et al. Among authors: shinjo k. Leuk Lymphoma. 2004 May;45(5):987-95. doi: 10.1080/10428190310001617222. Leuk Lymphoma. 2004. PMID: 15291359
Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.
Hirano I, Nakamura S, Yokota D, Ono T, Shigeno K, Fujisawa S, Shinjo K, Ohnishi K. Hirano I, et al. Among authors: shinjo k. J Biol Chem. 2009 Aug 14;284(33):22155-22165. doi: 10.1074/jbc.M808182200. Epub 2009 Mar 4. J Biol Chem. 2009. PMID: 19261608 Free PMC article.
Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines.
Naito K, Takeshita A, Shigeno K, Nakamura S, Fujisawa S, Shinjo K, Yoshida H, Ohnishi K, Mori M, Terakawa S, Ohno R. Naito K, et al. Among authors: shinjo k. Leukemia. 2000 Aug;14(8):1436-43. doi: 10.1038/sj.leu.2401851. Leukemia. 2000. PMID: 10942240
In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression.
Pan L, Ohnishi K, Zhang WJ, Yoshida H, Maksumova L, Muratkhodjaev F, Shigeno K, Nakamura S, Luo JM, Hao HL, Fujisawa S, Naito K, Shinjo K, Takeshita A, Ohno R. Pan L, et al. Among authors: shinjo k. Leukemia. 2000 Sep;14(9):1634-41. doi: 10.1038/sj.leu.2401872. Leukemia. 2000. PMID: 10995011
166 results