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The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Tucker TJ, Saggar S, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y. Tucker TJ, et al. Among authors: prasad s. Bioorg Med Chem Lett. 2008 May 1;18(9):2959-66. doi: 10.1016/j.bmcl.2008.03.064. Epub 2008 Mar 25. Bioorg Med Chem Lett. 2008. PMID: 18396399
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
Tucker TJ, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Reid JC, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y. Tucker TJ, et al. Among authors: prasad s. J Med Chem. 2008 Oct 23;51(20):6503-11. doi: 10.1021/jm800856c. Epub 2008 Oct 1. J Med Chem. 2008. PMID: 18826204
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Su DS, Lim JJ, Tinney E, Wan BL, Young MB, Anderson KD, Rudd D, Munshi V, Bahnck C, Felock PJ, Lu M, Lai MT, Touch S, Moyer G, Distefano DJ, Flynn JA, Liang Y, Sanchez R, Prasad S, Yan Y, Perlow-Poehnelt R, Torrent M, Miller M, Vacca JP, Williams TM, Anthony NJ. Su DS, et al. Among authors: prasad s. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5119-23. doi: 10.1016/j.bmcl.2009.07.031. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19631528
Evaluating the impact of performance status in elderly patients with glioblastoma.
Almeida ND, Rupp J, Gulzar B, Schrand TV, Madhugiri V, Fang M, Shekher R, Goulenko V, Goyal D, Prasad S, Milano MT, Prasad D. Almeida ND, et al. Among authors: prasad s. J Clin Neurosci. 2025 Jan 3;133:111028. doi: 10.1016/j.jocn.2024.111028. Online ahead of print. J Clin Neurosci. 2025. PMID: 39755030 Free article.
Melanoma toolkit for early detection for primary care clinicians: a 1-year follow-up on outcomes.
Diehl K, Stoos E, Becker A, Orfaly VE, Nelson J, Gillespie J, Ng J, Tobey T, Latour E, Ludzik J, Berry EG, Geller AC, Jacobe H, Leitenberger J, McClanahan D, Tran J, Prasad S, Mengden-Koon S, Nelson KC, Petering R, Verdieck A, Savory S, Smith EH, Tofte S, Weinstock MA, White K, Wisco O, Curiel-Lewandrowski C, Swetter SM, Witkowski AM, Ferris L, Black S, Xu R, Xu S, Leachman S. Diehl K, et al. Among authors: prasad s. Front Med (Lausanne). 2024 Dec 18;11:1500216. doi: 10.3389/fmed.2024.1500216. eCollection 2024. Front Med (Lausanne). 2024. PMID: 39744535 Free PMC article.
4,257 results