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Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.
Kozísek M, Sasková KG, Rezácová P, Brynda J, van Maarseveen NM, De Jong D, Boucher CA, Kagan RM, Nijhuis M, Konvalinka J. Kozísek M, et al. Among authors: konvalinka j. J Virol. 2008 Jun;82(12):5869-78. doi: 10.1128/JVI.02325-07. Epub 2008 Apr 9. J Virol. 2008. PMID: 18400858 Free PMC article.
Specificity mapping of HIV-1 protease by reduced bond inhibitors.
Majer P, Urban J, Gregorová E, Konvalinka J, Novek P, Stehlíková J, Andreánsky M, Sedlácek J, Strop P. Majer P, et al. Among authors: konvalinka j. Arch Biochem Biophys. 1993 Jul;304(1):1-8. doi: 10.1006/abbi.1993.1314. Arch Biochem Biophys. 1993. PMID: 8323274
Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase.
Konvalinka J, Litera J, Weber J, Vondrásek J, Hradílek M, Soucek M, Pichová I, Majer P, Strop P, Sedlácek J, Heuser AM, Kottler H, Kräusslich HG. Konvalinka J, et al. Eur J Biochem. 1997 Dec 1;250(2):559-66. doi: 10.1111/j.1432-1033.1997.0559a.x. Eur J Biochem. 1997. PMID: 9428710 Free article.
A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease.
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. Among authors: konvalinka j. Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):472-6. doi: 10.1107/s0907444900018928. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11223536
Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. Among authors: konvalinka j. J Med Chem. 2002 Mar 28;45(7):1432-8. doi: 10.1021/jm010979e. J Med Chem. 2002. PMID: 11906284
Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains.
Weber J, Mesters JR, Lepsík M, Prejdová J, Svec M, Sponarová J, Mlcochová P, Skalická K, Strísovský K, Uhlíková T, Soucek M, Machala L, Stanková M, Vondrásek J, Klimkait T, Kraeusslich HG, Hilgenfeld R, Konvalinka J. Weber J, et al. Among authors: konvalinka j. J Mol Biol. 2002 Dec 6;324(4):739-54. doi: 10.1016/s0022-2836(02)01139-7. J Mol Biol. 2002. PMID: 12460574
152 results