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Page 1
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: shelat a. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18420405 Free PMC article.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Among authors: shelat aa. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
Bringing chemistry to medicine to redefine the undruggable.
Deane CD, Fischer M, Shelat AA. Deane CD, et al. Among authors: shelat aa. Nat Chem Biol. 2024 Jul;20(7):807-809. doi: 10.1038/s41589-024-01598-1. Nat Chem Biol. 2024. PMID: 38609538 No abstract available.
ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.
Xie J, Kuriakose T, Bianski B, Twarog N, Savage E, Xu K, Zhu X, He C, Hansen B, Wang H, High A, Li Y, Rehg JE, Tillman HS, Freeman BB, Rankovic Z, Onar-Thomas A, Fan Y, Wu G, Peng J, Miller S, Baker SJ, Shelat AA, Tinkle CL. Xie J, et al. Among authors: shelat aa. Neuro Oncol. 2023 Oct 3;25(10):1828-1841. doi: 10.1093/neuonc/noad064. Neuro Oncol. 2023. PMID: 36971093 Free PMC article.
108 results