Alphey MS - Search Results

1

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.

Sgraja T, Alphey MS, Ghilagaber S, Marquez R, Robertson MN, Hemmings JL, Lauw S, Rohdich F, Bacher A, Eisenreich W, Illarionova V, Hunter WN. Sgraja T, et al. Among authors: alphey ms. FEBS J. 2008 Jun;275(11):2779-94. doi: 10.1111/j.1742-4658.2008.06418.x. Epub 2008 Apr 16. FEBS J. 2008. PMID: 18422643 Free PMC article.

2

Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase.

Miallau L, Alphey MS, Kemp LE, Leonard GA, McSweeney SM, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN. Miallau L, et al. Among authors: alphey ms. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9173-8. doi: 10.1073/pnas.1533425100. Epub 2003 Jul 23. Proc Natl Acad Sci U S A. 2003. PMID: 12878729 Free PMC article.

3

The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.

Kemp LE, Alphey MS, Bond CS, Ferguson MA, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN. Kemp LE, et al. Among authors: alphey ms. Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):45-52. doi: 10.1107/S0907444904025971. Epub 2004 Dec 17. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 15608374

4

Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.

Alphey MS, Yu W, Byres E, Li D, Hunter WN. Alphey MS, et al. J Biol Chem. 2005 Jan 28;280(4):3068-77. doi: 10.1074/jbc.M411069200. Epub 2004 Nov 6. J Biol Chem. 2005. PMID: 15531764 Free article.

5

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei.

Alphey MS, Hunter WN. Alphey MS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):504-8. doi: 10.1107/S1744309106014849. Epub 2006 May 5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16754967 Free PMC article.

6

Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity.

Byres E, Alphey MS, Smith TK, Hunter WN. Byres E, et al. Among authors: alphey ms. J Mol Biol. 2007 Aug 10;371(2):540-53. doi: 10.1016/j.jmb.2007.05.094. Epub 2007 Jun 4. J Mol Biol. 2007. PMID: 17583736

7

Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis.

Crane CM, Hirsch AK, Alphey MS, Sgraja T, Lauw S, Illarionova V, Rohdich F, Eisenreich W, Hunter WN, Bacher A, Diederich F. Crane CM, et al. Among authors: alphey ms. ChemMedChem. 2008 Jan;3(1):91-101. doi: 10.1002/cmdc.200700208. ChemMedChem. 2008. PMID: 18033714 Free article.

8

Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis.

Hirsch AK, Alphey MS, Lauw S, Seet M, Barandun L, Eisenreich W, Rohdich F, Hunter WN, Bacher A, Diederich F. Hirsch AK, et al. Among authors: alphey ms. Org Biomol Chem. 2008 Aug 7;6(15):2719-30. doi: 10.1039/b804375b. Epub 2008 Jun 2. Org Biomol Chem. 2008. PMID: 18633530 Free article.

9

Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme.

Fyfe PK, Alphey MS, Hunter WN. Fyfe PK, et al. Among authors: alphey ms. Mol Biochem Parasitol. 2010 Apr;170(2):93-9. doi: 10.1016/j.molbiopara.2009.12.011. Epub 2010 Jan 4. Mol Biochem Parasitol. 2010. PMID: 20045436 Free PMC article.

10

Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.

Alphey MS, Burton A, Urbaniak MD, Boons GJ, Ferguson MA, Hunter WN. Alphey MS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):829-34. doi: 10.1107/S1744309106028740. Epub 2006 Aug 11. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16946458 Free PMC article.

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