McKerrow JH - Search Results

1

Identification of a new class of nonpeptidic inhibitors of cruzain.

Brak K, Doyle PS, McKerrow JH, Ellman JA. Brak K, et al. Among authors: mckerrow jh. J Am Chem Soc. 2008 May 21;130(20):6404-10. doi: 10.1021/ja710254m. Epub 2008 Apr 25. J Am Chem Soc. 2008. PMID: 18435536 Free PMC article.

2

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. Among authors: mckerrow jh. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

3

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

4

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.

Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Brak K, et al. Among authors: mckerrow jh. J Med Chem. 2010 Feb 25;53(4):1763-73. doi: 10.1021/jm901633v. J Med Chem. 2010. PMID: 20088534 Free PMC article.

5

The Trypanosoma cruzi protease cruzain mediates immune evasion.

Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. Among authors: mckerrow jh. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.

6

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: mckerrow jh. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

7

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.

Doyle PS, Zhou YM, Engel JC, McKerrow JH. Doyle PS, et al. Among authors: mckerrow jh. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. doi: 10.1128/AAC.00436-07. Epub 2007 Aug 13. Antimicrob Agents Chemother. 2007. PMID: 17698625 Free PMC article.

8

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.

Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. Jaishankar P, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2008 Jan 15;18(2):624-8. doi: 10.1016/j.bmcl.2007.11.070. Epub 2007 Nov 22. Bioorg Med Chem Lett. 2008. PMID: 18055204

9

Development of protease inhibitors for protozoan infections.

McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. McKerrow JH, et al. Curr Opin Infect Dis. 2008 Dec;21(6):668-72. doi: 10.1097/QCO.0b013e328315cca9. Curr Opin Infect Dis. 2008. PMID: 18978536 Free PMC article. Review.

10

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Chen CK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. PLoS Negl Trop Dis. 2009. PMID: 19190730 Free PMC article.

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