Bjorkhem I - Search Results

1

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1.

White MA, Mast N, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. White MA, et al. Among authors: bjorkhem i. Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):487-95. doi: 10.1107/S0907444908004046. Epub 2008 Apr 19. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18453684 Free PMC article.

2

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.

Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9546-51. doi: 10.1073/pnas.0803717105. Epub 2008 Jul 9. Proc Natl Acad Sci U S A. 2008. PMID: 18621681 Free PMC article.

3

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

Mast N, Norcross R, Andersson U, Shou M, Nakayama K, Bjorkhem I, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. Biochemistry. 2003 Dec 9;42(48):14284-92. doi: 10.1021/bi035512f. Biochemistry. 2003. PMID: 14640697

4

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications.

Mast N, Andersson U, Nakayama K, Bjorkhem I, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. Arch Biochem Biophys. 2004 Aug 1;428(1):99-108. doi: 10.1016/j.abb.2004.05.012. Arch Biochem Biophys. 2004. PMID: 15234274

5

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

Murtazina DA, Andersson U, Hahn IS, Bjorkhem I, Ansari GA, Pikuleva IA. Murtazina DA, et al. Among authors: bjorkhem i. J Lipid Res. 2004 Dec;45(12):2345-53. doi: 10.1194/jlr.M400300-JLR200. Epub 2004 Sep 1. J Lipid Res. 2004. PMID: 15342675 Free article.

6

Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.

Pikuleva IA, Puchkaev A, Björkhem I. Pikuleva IA, et al. Among authors: bjorkhem i. Biochemistry. 2001 Jun 26;40(25):7621-9. doi: 10.1021/bi010193i. Biochemistry. 2001. PMID: 11412116

7

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis.

Mast N, Graham SE, Andersson U, Bjorkhem I, Hill C, Peterson J, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. Biochemistry. 2005 Mar 8;44(9):3259-71. doi: 10.1021/bi047566a. Biochemistry. 2005. PMID: 15736936

8

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.

Mast N, Anderson KW, Lin JB, Li Y, Turko IV, Tatsuoka C, Bjorkhem I, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. J Biol Chem. 2017 Mar 24;292(12):4913-4924. doi: 10.1074/jbc.M116.774760. Epub 2017 Feb 11. J Biol Chem. 2017. PMID: 28190002 Free PMC article.

9

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

Mast N, Lin JB, Anderson KW, Bjorkhem I, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. PLoS One. 2017 Oct 26;12(10):e0187168. doi: 10.1371/journal.pone.0187168. eCollection 2017. PLoS One. 2017. PMID: 29073233 Free PMC article.

10

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.

Mast N, Murtazina D, Liu H, Graham SE, Bjorkhem I, Halpert JR, Peterson J, Pikuleva IA. Mast N, et al. Among authors: bjorkhem i. Biochemistry. 2006 Apr 11;45(14):4396-404. doi: 10.1021/bi052654w. Biochemistry. 2006. PMID: 16584175

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