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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. Kirkpatrick CL, et al. Among authors: wollheim cb. J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784843 Free PMC article.
Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.
Perakakis N, Danassi D, Alt M, Tsaroucha E, Mehana AE, Rimmer N, Laubner K, Wang H, Wollheim CB, Seufert J, Päth G. Perakakis N, et al. Among authors: wollheim cb. Mol Cell Endocrinol. 2012 Nov 5;363(1-2):20-6. doi: 10.1016/j.mce.2012.07.003. Epub 2012 Jul 16. Mol Cell Endocrinol. 2012. PMID: 22801105
366 results