Samudio I - Search Results

1

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.

Samudio I, Kurinna S, Ruvolo P, Korchin B, Kantarjian H, Beran M, Dunner K Jr, Kondo S, Andreeff M, Konopleva M. Samudio I, et al. Mol Cancer Ther. 2008 May;7(5):1130-9. doi: 10.1158/1535-7163.MCT-07-0553. Mol Cancer Ther. 2008. PMID: 18483301 Free PMC article.

2

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

Zeng Z, Samudio IJ, Munsell M, An J, Huang Z, Estey E, Andreeff M, Konopleva M. Zeng Z, et al. Mol Cancer Ther. 2006 Dec;5(12):3113-21. doi: 10.1158/1535-7163.MCT-06-0228. Mol Cancer Ther. 2006. PMID: 17172414

3

Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.

Kojima K, Konopleva M, Samudio IJ, Ruvolo V, Andreeff M. Kojima K, et al. Cancer Res. 2007 Apr 1;67(7):3210-9. doi: 10.1158/0008-5472.CAN-06-2712. Cancer Res. 2007. PMID: 17409429

4

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.

Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M. Samudio I, et al. Mol Cancer Ther. 2005 Dec;4(12):1982-92. doi: 10.1158/1535-7163.MCT-05-0247. Mol Cancer Ther. 2005. PMID: 16373713

5

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis.

Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M. Samudio I, et al. Mol Pharmacol. 2006 Apr;69(4):1182-93. doi: 10.1124/mol.105.018051. Epub 2006 Jan 12. Mol Pharmacol. 2006. PMID: 16410408

6

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism.

Samudio I, Fiegl M, Andreeff M. Samudio I, et al. Cancer Res. 2009 Mar 15;69(6):2163-6. doi: 10.1158/0008-5472.CAN-08-3722. Epub 2009 Mar 3. Cancer Res. 2009. PMID: 19258498 Free PMC article. Review.

7

Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.

Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S. Jutooru I, et al. Among authors: samudio i. Mol Pharmacol. 2010 Aug;78(2):226-36. doi: 10.1124/mol.110.064451. Epub 2010 May 20. Mol Pharmacol. 2010. PMID: 20488920 Free PMC article.

8

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.

Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. Contractor R, et al. Cancer Res. 2005 Apr 1;65(7):2890-8. doi: 10.1158/0008-5472.CAN-04-3781. Cancer Res. 2005. PMID: 15805291

9

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M. Zeng Z, et al. Cancer Res. 2006 Apr 1;66(7):3737-46. doi: 10.1158/0008-5472.CAN-05-1278. Cancer Res. 2006. PMID: 16585200

10

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

Kojima K, Konopleva M, Samudio IJ, Schober WD, Bornmann WG, Andreeff M. Kojima K, et al. Cell Cycle. 2006 Dec;5(23):2778-86. doi: 10.4161/cc.5.23.3520. Epub 2006 Dec 1. Cell Cycle. 2006. PMID: 17172851

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