Fahmi OA - Search Results

1

A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro.

Fahmi OA, Maurer TS, Kish M, Cardenas E, Boldt S, Nettleton D. Fahmi OA, et al. Drug Metab Dispos. 2008 Aug;36(8):1698-708. doi: 10.1124/dmd.107.018663. Epub 2008 May 19. Drug Metab Dispos. 2008. PMID: 18490437

2

Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.

Kalgutkar AS, Zhou S, Fahmi OA, Taylor TJ. Kalgutkar AS, et al. Among authors: fahmi oa. Drug Metab Dispos. 2003 May;31(5):596-605. doi: 10.1124/dmd.31.5.596. Drug Metab Dispos. 2003. PMID: 12695348

3

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM. Ripp SL, et al. Among authors: fahmi oa. Drug Metab Dispos. 2006 Oct;34(10):1742-8. doi: 10.1124/dmd.106.010132. Epub 2006 Jul 12. Drug Metab Dispos. 2006. PMID: 16837568

4

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.

Youdim KA, Zayed A, Dickins M, Phipps A, Griffiths M, Darekar A, Hyland R, Fahmi O, Hurst S, Plowchalk DR, Cook J, Guo F, Obach RS. Youdim KA, et al. Br J Clin Pharmacol. 2008 May;65(5):680-92. doi: 10.1111/j.1365-2125.2007.03070.x. Epub 2008 Feb 14. Br J Clin Pharmacol. 2008. PMID: 18279465 Free PMC article.

5

Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes.

Fahmi OA, Boldt S, Kish M, Obach RS, Tremaine LM. Fahmi OA, et al. Drug Metab Dispos. 2008 Sep;36(9):1971-4. doi: 10.1124/dmd.108.021907. Epub 2008 Jun 2. Drug Metab Dispos. 2008. PMID: 18519654

6

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction.

Fahmi OA, Hurst S, Plowchalk D, Cook J, Guo F, Youdim K, Dickins M, Phipps A, Darekar A, Hyland R, Obach RS. Fahmi OA, et al. Drug Metab Dispos. 2009 Aug;37(8):1658-66. doi: 10.1124/dmd.108.026252. Epub 2009 Apr 30. Drug Metab Dispos. 2009. PMID: 19406954

7

Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes.

Fahmi OA, Kish M, Boldt S, Obach RS. Fahmi OA, et al. Drug Metab Dispos. 2010 Sep;38(9):1605-11. doi: 10.1124/dmd.110.033126. Epub 2010 Jun 21. Drug Metab Dispos. 2010. PMID: 20566695

8

Evaluation of models for predicting drug-drug interactions due to induction.

Fahmi OA, Ripp SL. Fahmi OA, et al. Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1399-416. doi: 10.1517/17425255.2010.516251. Expert Opin Drug Metab Toxicol. 2010. PMID: 20955108 Review.

9

How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.

Kraynov E, Martin SW, Hurst S, Fahmi OA, Dowty M, Cronenberger C, Loi CM, Kuang B, Fields O, Fountain S, Awwad M, Wang D. Kraynov E, et al. Among authors: fahmi oa. Drug Metab Dispos. 2011 Oct;39(10):1779-83. doi: 10.1124/dmd.111.040808. Epub 2011 Jul 18. Drug Metab Dispos. 2011. PMID: 21768274 Review.

10

Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data.

Gupta P, Alvey C, Wang R, Dowty ME, Fahmi OA, Walsky RL, Riese RJ, Krishnaswami S. Gupta P, et al. Among authors: fahmi oa. Br J Clin Pharmacol. 2012 Jul;74(1):109-15. doi: 10.1111/j.1365-2125.2012.04168.x. Br J Clin Pharmacol. 2012. PMID: 22233204 Free PMC article. Clinical Trial.

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