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Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA. Luo L, et al. Among authors: coales sj. J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21. J Am Chem Soc. 2008. PMID: 18491908
Isofagomine induced stabilization of glucocerebrosidase.
Kornhaber GJ, Tropak MB, Maegawa GH, Tuske SJ, Coales SJ, Mahuran DJ, Hamuro Y. Kornhaber GJ, et al. Among authors: coales sj. Chembiochem. 2008 Nov 3;9(16):2643-9. doi: 10.1002/cbic.200800249. Chembiochem. 2008. PMID: 18932186 Free PMC article.
Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.
Tropak MB, Kornhaber GJ, Rigat BA, Maegawa GH, Buttner JD, Blanchard JE, Murphy C, Tuske SJ, Coales SJ, Hamuro Y, Brown ED, Mahuran DJ. Tropak MB, et al. Among authors: coales sj. Chembiochem. 2008 Nov 3;9(16):2650-62. doi: 10.1002/cbic.200800304. Chembiochem. 2008. PMID: 18972510 Free PMC article.
22 results