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Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Rappa F, Pitruzzella A, Marino Gammazza A, Barone R, Mocciaro E, Tomasello G, Carini F, Farina F, Zummo G, Conway de Macario E, Macario AJ, Cappello F. Rappa F, et al. Among authors: zummo g. Cell Stress Chaperones. 2016 Sep;21(5):927-33. doi: 10.1007/s12192-016-0721-5. Epub 2016 Aug 4. Cell Stress Chaperones. 2016. PMID: 27491302 Free PMC article.
Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Marino Gammazza A, Campanella C, Barone R, Caruso Bavisotto C, Gorska M, Wozniak M, Carini F, Cappello F, D'Anneo A, Lauricella M, Zummo G, Conway de Macario E, Macario AJ, Di Felice V. Marino Gammazza A, et al. Among authors: zummo g. Cancer Lett. 2017 Jan 28;385:75-86. doi: 10.1016/j.canlet.2016.10.045. Epub 2016 Nov 9. Cancer Lett. 2017. PMID: 27836734 Free article.
The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells.
Caruso Bavisotto C, Nikolic D, Marino Gammazza A, Barone R, Lo Cascio F, Mocciaro E, Zummo G, Conway de Macario E, Macario AJ, Cappello F, Giacalone V, Pace A, Barone G, Palumbo Piccionello A, Campanella C. Caruso Bavisotto C, et al. Among authors: zummo g. J Inorg Biochem. 2017 May;170:8-16. doi: 10.1016/j.jinorgbio.2017.02.004. Epub 2017 Feb 10. J Inorg Biochem. 2017. PMID: 28212901 Free article.
Hsp60 and Hspl0 as antitumor molecular agents.
Cappello F, Czarnecka AM, La Rocca G, Di Stefano A, Zummo G, Macario AJ. Cappello F, et al. Among authors: zummo g. Cancer Biol Ther. 2007 Apr;6(4):487-9. doi: 10.4161/cbt.6.4.4087. Cancer Biol Ther. 2007. PMID: 17457039 Free article.
Hsp60 is actively secreted by human tumor cells.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, Cappello F. Merendino AM, et al. Among authors: zummo g. PLoS One. 2010 Feb 16;5(2):e9247. doi: 10.1371/journal.pone.0009247. PLoS One. 2010. PMID: 20169074 Free PMC article.
134 results