Lavoie EJ - Search Results

1

Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, Lavoie EJ. Feng W, et al. Among authors: lavoie ej. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3570-2. doi: 10.1016/j.bmcl.2008.05.005. Epub 2008 May 6. Bioorg Med Chem Lett. 2008. PMID: 18511275

2

Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors.

Sun Q, Gatto B, Yu C, Liu A, Liu LF, LaVoie EJ. Sun Q, et al. Among authors: lavoie ej. J Med Chem. 1995 Sep 1;38(18):3638-44. doi: 10.1021/jm00018a024. J Med Chem. 1995. PMID: 7658451

3

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles.

Weinkauf RL, Chen AY, Yu C, Liu L, Barrows L, LaVoie EJ. Weinkauf RL, et al. Among authors: lavoie ej. Bioorg Med Chem. 1994 Aug;2(8):781-6. doi: 10.1016/s0968-0896(00)82177-x. Bioorg Med Chem. 1994. PMID: 7894971

4

Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.

Meegalla SK, Stevens GJ, McQueen CA, Chen AY, Yu C, Liu LF, Barrows LR, LaVoie EJ. Meegalla SK, et al. Among authors: lavoie ej. J Med Chem. 1994 Sep 30;37(20):3434-9. doi: 10.1021/jm00046a028. J Med Chem. 1994. PMID: 7932571

5

Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.

Kim JS, Gatto B, Yu C, Liu A, Liu LF, LaVoie EJ. Kim JS, et al. Among authors: lavoie ej. J Med Chem. 1996 Feb 16;39(4):992-8. doi: 10.1021/jm950412w. J Med Chem. 1996. PMID: 8632422

6

Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne.

Gatto B, Sanders MM, Yu C, Wu HY, Makhey D, LaVoie EJ, Liu LF. Gatto B, et al. Among authors: lavoie ej. Cancer Res. 1996 Jun 15;56(12):2795-800. Cancer Res. 1996. PMID: 8665516

7

Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons.

Kim JS, Sun Q, Gatto B, Yu C, Liu A, Liu LF, LaVoie EJ. Kim JS, et al. Among authors: lavoie ej. Bioorg Med Chem. 1996 Apr;4(4):621-30. doi: 10.1016/0968-0896(96)00047-8. Bioorg Med Chem. 1996. PMID: 8735851

8

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons.

Makhey D, Gatto B, Yu C, Liu A, Liu LF, LaVoie EJ. Makhey D, et al. Among authors: lavoie ej. Bioorg Med Chem. 1996 Jun;4(6):781-91. doi: 10.1016/0968-0896(96)00054-5. Bioorg Med Chem. 1996. PMID: 8818227

9

Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: evidence for both intercalative and minor groove binding properties.

Pilch DS, Xu Z, Sun Q, Lavoie EJ, Liu LF, Geacintov NE, Breslauer KJ. Pilch DS, et al. Among authors: lavoie ej. Drug Des Discov. 1996 Apr;13(3-4):115-33. Drug Des Discov. 1996. PMID: 8874049

10

Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons.

Kim JS, Yu C, Liu A, Liu LF, LaVoie EJ. Kim JS, et al. Among authors: lavoie ej. J Med Chem. 1997 Aug 29;40(18):2818-24. doi: 10.1021/jm960658g. J Med Chem. 1997. PMID: 9288163

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