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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D. Xu D, et al. Among authors: salem m. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4. J Pharmacol Exp Ther. 2008. PMID: 18524979
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.
Wu TY, Juteau H, Ducharme Y, Friesen RW, Guiral S, Dufresne L, Poirier H, Salem M, Riendeau D, Mancini J, Brideau C. Wu TY, et al. Among authors: salem m. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6978-82. doi: 10.1016/j.bmcl.2010.09.129. Epub 2010 Oct 19. Bioorg Med Chem Lett. 2010. PMID: 20965723
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.
Ducharme Y, Blouin M, Brideau C, Châteauneuf A, Gareau Y, Grimm EL, Juteau H, Laliberté S, MacKay B, Massé F, Ouellet M, Salem M, Styhler A, Friesen RW. Ducharme Y, et al. Among authors: salem m. ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. doi: 10.1021/ml100029k. eCollection 2010 Jul 8. ACS Med Chem Lett. 2010. PMID: 24900191 Free PMC article.
Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Gallant M, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Huang Z, Lacombe P, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini J, Masson P, Mastracchio A, Nicholson D, Nicoll-Griffith DA, Perrier H, Salem M, Styhler A, Young RN, Girard Y. Gallant M, et al. Among authors: salem m. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1407-12. doi: 10.1016/j.bmcl.2008.01.004. Epub 2008 Jan 8. Bioorg Med Chem Lett. 2008. PMID: 18207397
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Lacombe P, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Gallant M, Girard Y, Huang Z, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini JA, Masson P, Nicholson DW, Nicoll-Griffith DA, Salem M, Styhler A, Young RN. Lacombe P, et al. Among authors: salem m. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5266-9. doi: 10.1016/j.bmcl.2009.03.105. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19640717
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Lacombe P, Deschênes D, Dubé D, Dubé L, Gallant M, Macdonald D, Mastracchio A, Perrier H, Charleson S, Huang Z, Laliberté F, Liu S, Mancini JA, Masson P, Salem M, Styhler A, Girard Y. Lacombe P, et al. Among authors: salem m. Bioorg Med Chem Lett. 2006 May 15;16(10):2608-12. doi: 10.1016/j.bmcl.2006.02.043. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516471
Preferential inhibition of human phosphodiesterase 4 by ibudilast.
Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K. Huang Z, et al. Among authors: salem m. Life Sci. 2006 May 1;78(23):2663-8. doi: 10.1016/j.lfs.2005.10.026. Epub 2005 Nov 28. Life Sci. 2006. PMID: 16313925
Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm Spodoptera litura: design, characterization, in vivo bio-evaluation, toxicological effectiveness, and study their mode of action.
Elsisi DM, Abusaif MS, El-Said E, Elqady EM, Salem MA, Ammar YA, Ragab A. Elsisi DM, et al. Among authors: salem ma. RSC Adv. 2025 Jan 16;15(2):1391-1406. doi: 10.1039/d4ra08096c. eCollection 2025 Jan 9. RSC Adv. 2025. PMID: 39822566 Free PMC article.
2,003 results