Shibata Y - Search Results

1

A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel.

Yoshizumi T, Takahashi H, Miyazoe H, Sugimoto Y, Tsujita T, Kato T, Ito H, Kawamoto H, Hirayama M, Ichikawa D, Azuma-Kanoh T, Ozaki S, Shibata Y, Tani T, Chiba M, Ishii Y, Okuda S, Tadano K, Fukuroda T, Okamoto O, Ohta H. Yoshizumi T, et al. Among authors: shibata y. J Med Chem. 2008 Jul 10;51(13):4021-9. doi: 10.1021/jm701590h. Epub 2008 Jun 7. J Med Chem. 2008. PMID: 18537234

2

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

Shibata Y, Takahashi H, Chiba M, Ishii Y. Shibata Y, et al. Drug Metab Dispos. 2002 Aug;30(8):892-6. doi: 10.1124/dmd.30.8.892. Drug Metab Dispos. 2002. PMID: 12124306

3

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio.

Ohe T, Sato M, Tanaka S, Fujino N, Hata M, Shibata Y, Kanatani A, Fukami T, Yamazaki M, Chiba M, Ishii Y. Ohe T, et al. Among authors: shibata y. Drug Metab Dispos. 2003 Oct;31(10):1251-4. doi: 10.1124/dmd.31.10.1251. Drug Metab Dispos. 2003. PMID: 12975334

4

Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

Yoshizumi T, Takahashi H, Ohtake N, Jona H, Sato Y, Kishino H, Sakamoto T, Ozaki S, Takahashi H, Shibata Y, Ishii Y, Saito M, Okada M, Hayama T, Nishikibe M. Yoshizumi T, et al. Among authors: shibata y. Bioorg Med Chem. 2004 May 1;12(9):2139-50. doi: 10.1016/j.bmc.2004.02.033. Bioorg Med Chem. 2004. PMID: 15080914

5

A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method.

Shibata Y, Takahashi H, Chiba M, Ishii Y. Shibata Y, et al. Drug Metab Pharmacokinet. 2008;23(5):328-39. doi: 10.2133/dmpk.23.328. Drug Metab Pharmacokinet. 2008. PMID: 18974610 Free article.

6

A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.

Inoue K, Shibata Y, Takahashi H, Ohe T, Chiba M, Ishii Y. Inoue K, et al. Among authors: shibata y. Drug Metab Pharmacokinet. 2009;24(3):245-54. doi: 10.2133/dmpk.24.245. Drug Metab Pharmacokinet. 2009. PMID: 19571436 Free article.

7

Utility of cryopreserved hepatocytes suspended in serum to predict hepatic clearance in dogs and monkeys.

Shibata Y, Kuze J, Chiba M. Shibata Y, et al. Drug Metab Pharmacokinet. 2014;29(2):168-76. doi: 10.2133/dmpk.dmpk-13-rg-083. Epub 2013 Sep 17. Drug Metab Pharmacokinet. 2014. PMID: 24042473 Free article.

8

The role of extrahepatic metabolism in the pharmacokinetics of the targeted covalent inhibitors afatinib, ibrutinib, and neratinib.

Shibata Y, Chiba M. Shibata Y, et al. Drug Metab Dispos. 2015 Mar;43(3):375-84. doi: 10.1124/dmd.114.061424. Epub 2014 Dec 10. Drug Metab Dispos. 2015. PMID: 25504185

9

Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).

Day JEH, Berdini V, Castro J, Chessari G, Davies TG, Day PJ, St Denis JD, Fujiwara H, Fukaya S, Hamlett CCF, Hearn K, Hiscock SD, Holvey RS, Ito S, Kandola N, Kodama Y, Liebeschuetz JW, Martins V, Matsuo K, Mortenson PN, Muench S, Nakatsuru Y, Ochiiwa H, Palmer N, Peakman T, Price A, Reader M, Rees DC, Rich SJ, Shah A, Shibata Y, Smyth T, Twigg DG, Wallis NG, Williams G, Wilsher NE, Woodhead A, Shimamura T, Johnson CN. Day JEH, et al. Among authors: shibata y. J Med Chem. 2024 Mar 28;67(6):4655-4675. doi: 10.1021/acs.jmedchem.3c02118. Epub 2024 Mar 10. J Med Chem. 2024. PMID: 38462716

10

Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).

Shibata Y, Kagechika K, Yamaguchi M, Kubo H, Usui H. Shibata Y, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7075-9. doi: 10.1016/j.bmcl.2012.09.092. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084275

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