Lubisch W - Search Results

1

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.

Penning TD, Zhu GD, Gandhi VB, Gong J, Thomas S, Lubisch W, Grandel R, Wernet W, Park CH, Fry EH, Liu X, Shi Y, Klinghofer V, Johnson EF, Donawho CK, Frost DJ, Bontcheva-Diaz V, Bouska JJ, Olson AM, Marsh KC, Luo Y, Rosenberg SH, Giranda VL. Penning TD, et al. Among authors: lubisch w. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. doi: 10.1016/j.bmc.2008.05.044. Epub 2008 May 27. Bioorg Med Chem. 2008. PMID: 18541433

2

Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. [email protected].

Geneste H, Backfisch G, Braje W, Delzer J, Haupt A, Hutchins CW, King LL, Lubisch W, Steiner G, Teschendorf HJ, Unger L, Wernet W. Geneste H, et al. Among authors: lubisch w. Bioorg Med Chem Lett. 2006 Feb;16(3):658-62. doi: 10.1016/j.bmcl.2005.10.035. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16271293

3

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.

Oost T, Backfisch G, Bhowmik S, van Gaalen MM, Geneste H, Hornberger W, Lubisch W, Netz A, Unger L, Wernet W. Oost T, et al. Among authors: lubisch w. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3828-31. doi: 10.1016/j.bmcl.2011.03.012. Epub 2011 Mar 6. Bioorg Med Chem Lett. 2011. PMID: 21605973

4

Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.

Lubisch W, Beckenbach E, Bopp S, Hofmann HP, Kartal A, Kästel C, Lindner T, Metz-Garrecht M, Reeb J, Regner F, Vierling M, Möller A. Lubisch W, et al. J Med Chem. 2003 Jun 5;46(12):2404-12. doi: 10.1021/jm0210717. J Med Chem. 2003. PMID: 12773044

5

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts.

Neuhof C, Fabiunke V, Deibele K, Speth M, Möller A, Lubisch W, Fritz H, Tillmanns H, Neuhof H. Neuhof C, et al. Among authors: lubisch w. Biol Chem. 2004 Nov;385(11):1077-82. doi: 10.1515/BC.2004.139. Biol Chem. 2004. PMID: 15576328

6

A novel water-soluble and cell-permeable calpain inhibitor protects myocardial and mitochondrial function in postischemic reperfusion.

Neuhof C, Götte O, Trumbeckaite S, Attenberger M, Kuzkaya N, Gellerich F, Möller A, Lubisch W, Speth M, Tillmanns H, Neuhof H. Neuhof C, et al. Among authors: lubisch w. Biol Chem. 2003 Dec;384(12):1597-603. doi: 10.1515/BC.2003.177. Biol Chem. 2003. PMID: 14719802

7

Calpain inhibitor A-558693 in experimental focal cerebral ischemia in rats.

Liebetrau M, Martens H, Thomassen N, Burggraf D, Gabrijelcic-Geiger D, Lubisch W, Möller A, Hamann GF. Liebetrau M, et al. Among authors: lubisch w. Neurol Res. 2005 Jul;27(5):466-70. doi: 10.1179/016164105X15712. Neurol Res. 2005. PMID: 15978171

8

Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.

Lubisch W, Behl B, Henn C, Hofmann HP, Reeb J, Regner F, Vierling M. Lubisch W, et al. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2113-6. doi: 10.1016/s0960-894x(02)00335-9. Bioorg Med Chem Lett. 2002. PMID: 12127516

9

Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors.

Lubisch W, Möller A. Lubisch W, et al. Bioorg Med Chem Lett. 2002 May 20;12(10):1335-8. doi: 10.1016/s0960-894x(02)00176-2. Bioorg Med Chem Lett. 2002. PMID: 11992771

10

Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors.

Lubisch W, Hofmann HP, Treiber HJ, Möller A. Lubisch W, et al. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2187-91. doi: 10.1016/s0960-894x(00)00430-3. Bioorg Med Chem Lett. 2000. PMID: 11012026

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