Nomeir AA - Search Results

1

Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.

Paliwal S, Reichard GA, Shah S, Wrobleski ML, Wang C, Stengone C, Tsui HC, Xiao D, Duffy RA, Lachowicz JE, Nomeir AA, Varty GB, Shih NY. Paliwal S, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4168-71. doi: 10.1016/j.bmcl.2008.05.082. Epub 2008 May 24. Bioorg Med Chem Lett. 2008. PMID: 18547807

2

Discovery of a series of potent, orally active α,α-disubstituted piperidine NK(1) antagonists.

Xiao D, Wang C, Palani A, Tsui HC, Reichard G, Paliwal S, Shih NY, Aslanian R, Duffy R, Lachowicz J, Varty G, Morgan C, Liu F, Nomeir A. Xiao D, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6313-5. doi: 10.1016/j.bmcl.2010.08.059. Epub 2010 Aug 15. Bioorg Med Chem Lett. 2010. PMID: 20846861

3

Cyclic urea derivatives as potent NK1 selective antagonists.

Shue HJ, Chen X, Shih NY, Blythin DJ, Paliwal S, Lin L, Gu D, Schwerdt JH, Shah S, Reichard GA, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Liu F, Nomeir AA, Morgan CA, Varty GB. Shue HJ, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3896-9. doi: 10.1016/j.bmcl.2005.05.111. Bioorg Med Chem Lett. 2005. PMID: 16019209

4

Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions.

Shue HJ, Chen X, Schwerdt JH, Paliwal S, Blythin DJ, Lin L, Gu D, Wang C, Reichard GA, Wang H, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Nomeir AA, Morgan CA, Varty GB, Shih NY. Shue HJ, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1065-9. doi: 10.1016/j.bmcl.2005.10.072. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290143

5

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.

Josien H, Bara T, Rajagopalan M, Clader JW, Greenlee WJ, Favreau L, Hyde LA, Nomeir AA, Parker EM, Song L, Zhang L, Zhang Q. Josien H, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6032-7. doi: 10.1016/j.bmcl.2009.09.055. Epub 2009 Sep 19. Bioorg Med Chem Lett. 2009. PMID: 19800786

6

Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.

Ting PC, Lee JF, Shih NY, Piwinski JJ, Anthes JC, Chapman RW, Rizzo CA, Hey JA, Ng K, Nomeir AA. Ting PC, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2125-8. doi: 10.1016/s0960-894x(02)00340-2. Bioorg Med Chem Lett. 2002. PMID: 12127519

7

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann TO, Hruza A, Madison V, Nomeir AA, Wang Y, Lees E, Parry D, Sgambellone N, Seghezzi W, Schultz L, Shanahan F, Wiswell D, Xu X, Zhou Q, James RA, Paradkar VM, Park H, Rokosz LR, Stauffer TM, Guzi TJ. Paruch K, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6220-3. doi: 10.1016/j.bmcl.2007.09.017. Epub 2007 Sep 8. Bioorg Med Chem Lett. 2007. PMID: 17904841

8

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.

McBriar MD, Clader JW, Chu I, Del Vecchio RA, Favreau L, Greenlee WJ, Hyde LA, Nomeir AA, Parker EM, Pissarnitski DA, Song L, Zhang L, Zhao Z. McBriar MD, et al. Among authors: nomeir aa. Bioorg Med Chem Lett. 2008 Jan 1;18(1):215-9. doi: 10.1016/j.bmcl.2007.10.092. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 17988864

9

Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability.

Njoroge FG, Vibulbhan B, Shi X, Strickland C, Kirschmeier P, Bishop R, Nomeir A, Girijavallabhan V. Njoroge FG, et al. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5899-902. doi: 10.1016/j.bmcl.2004.09.020. Bioorg Med Chem Lett. 2004. PMID: 15501065

10

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].

Bennett F, Saksena AK, Lovey RG, Liu YT, Patel NM, Pinto P, Pike R, Jao E, Girijavallabhan VM, Ganguly AK, Loebenberg D, Wang H, Cacciapuoti A, Moss E, Menzel F, Hare RS, Nomeir A. Bennett F, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):186-90. doi: 10.1016/j.bmcl.2005.09.031. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16260134

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