Leventhal L - Search Results

1

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC. Mahaney PE, et al. Among authors: leventhal l. J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17. J Med Chem. 2008. PMID: 18557608

2

Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models.

Deecher DC, Alfinito PD, Leventhal L, Cosmi S, Johnston GH, Merchenthaler I, Winneker R. Deecher DC, et al. Among authors: leventhal l. Endocrinology. 2007 Mar;148(3):1376-83. doi: 10.1210/en.2006-1163. Epub 2006 Nov 22. Endocrinology. 2007. PMID: 17122073

3

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.

Vu AT, Cohn ST, Zhang P, Kim CY, Mahaney PE, Bray JA, Johnston GH, Koury EJ, Cosmi SA, Deecher DC, Smith VA, Harrison JE, Leventhal L, Whiteside GT, Kennedy JD, Trybulski EJ. Vu AT, et al. Among authors: leventhal l. J Med Chem. 2010 Mar 11;53(5):2051-62. doi: 10.1021/jm901559e. J Med Chem. 2010. PMID: 20131864

4

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: leventhal l. J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t. J Med Chem. 2010. PMID: 20462211

5

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).

O'Neill DJ, Adedoyin A, Bray JA, Deecher DC, Fensome A, Goldberg JA, Harrison J, Leventhal L, Mann C, Mark L, Nogle L, Sullivan NR, Spangler TB, Terefenko EA, Trybulski EJ, Uveges AJ, Vu A, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: leventhal l. J Med Chem. 2011 Oct 13;54(19):6824-31. doi: 10.1021/jm200733r. Epub 2011 Sep 14. J Med Chem. 2011. PMID: 21916421

6

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.

Mahaney PE, Vu AT, McComas CC, Zhang P, Nogle LM, Watts WL, Sarkahian A, Leventhal L, Sullivan NR, Uveges AJ, Trybulski EJ. Mahaney PE, et al. Among authors: leventhal l. Bioorg Med Chem. 2006 Dec 15;14(24):8455-66. doi: 10.1016/j.bmc.2006.08.039. Epub 2006 Sep 14. Bioorg Med Chem. 2006. PMID: 16973367

7

Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.

Sipe K, Leventhal L, Burroughs K, Cosmi S, Johnston GH, Deecher DC. Sipe K, et al. Among authors: leventhal l. Brain Res. 2004 Dec 3;1028(2):191-202. doi: 10.1016/j.brainres.2004.09.012. Brain Res. 2004. PMID: 15527744

8

The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.

Maswood N, Cosmi S, Alfinito PD, Leventhal L, Deecher DC. Maswood N, et al. Among authors: leventhal l. Neuroendocrinology. 2006;84(5):330-8. doi: 10.1159/000098322. Epub 2006 Dec 28. Neuroendocrinology. 2006. PMID: 17192701

9

Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain.

Leventhal L, Smith V, Hornby G, Andree TH, Brandt MR, Rogers KE. Leventhal L, et al. J Pharmacol Exp Ther. 2007 Mar;320(3):1178-85. doi: 10.1124/jpet.106.109728. Epub 2006 Dec 1. J Pharmacol Exp Ther. 2007. PMID: 17142646

10

Effect of calcium channel modulators on temperature regulation in ovariectomized rats.

Leventhal L, Cosmi S, Deecher D. Leventhal L, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):511-20. doi: 10.1016/j.pbb.2005.01.005. Pharmacol Biochem Behav. 2005. PMID: 15740794

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