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Page 1
Cholesterol increases the open probability of cardiac KACh currents.
Bukiya AN, Osborn CV, Kuntamallappanavar G, Toth PT, Baki L, Kowalsky G, Oh MJ, Dopico AM, Levitan I, Rosenhouse-Dantsker A. Bukiya AN, et al. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13. doi: 10.1016/j.bbamem.2015.07.007. Epub 2015 Jul 18. Biochim Biophys Acta. 2015. PMID: 26196595 Free article.
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).
Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: kowalsky gb. J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20. J Biol Chem. 2012. PMID: 22995912 Free PMC article.