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Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.
Jenkins EC, Ye L, Gu H, Ni SA, Duncan CJ, Velinov M, Pang D, Krinsky-McHale SJ, Zigman WB, Schupf N, Silverman WP. Jenkins EC, et al. Among authors: ye l. Neurosci Lett. 2008 Aug 8;440(3):340-3. doi: 10.1016/j.neulet.2008.05.098. Epub 2008 Jun 18. Neurosci Lett. 2008. PMID: 18571319 Free PMC article.
We have reported previously that telomeres (ends of chromosomes consisting of highly conserved TTAGGG repeats) were shorter in metaphase and interphase preparations in T lymphocytes from short-term whole blood cultures of women with Down syndrome (DS) and dementia compared to age …
We have reported previously that telomeres (ends of chromosomes consisting of highly conserved TTAGGG repeats) were shorter in metaphase and …
Successful aging in a 70-year-old man with down syndrome: a case study.
Krinsky-McHale SJ, Devenny DA, Gu H, Jenkins EC, Kittler P, Murty VV, Schupf N, Scotto L, Tycko B, Urv TK, Ye L, Zigman WB, Silverman W. Krinsky-McHale SJ, et al. Among authors: ye l. Intellect Dev Disabil. 2008 Jun;46(3):215-28. doi: 10.1352/2008.46:215-228. Intellect Dev Disabil. 2008. PMID: 18578579
Does the cryogenic freezing process cause shorter telomeres?
Jenkins EC, Ye L, Silverman WP. Jenkins EC, et al. Among authors: ye l. Cryobiology. 2012 Aug;65(1):72-3. doi: 10.1016/j.cryobiol.2012.03.005. Epub 2012 Mar 29. Cryobiology. 2012. PMID: 22465657 Free PMC article.
Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns.
Jenkins EC, Ye L, Velinov M, Krinsky-McHale SJ, Zigman WB, Schupf N, Silverman WP. Jenkins EC, et al. Among authors: ye l. Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):598-604. doi: 10.1002/ajmg.b.32066. Epub 2012 May 16. Am J Med Genet B Neuropsychiatr Genet. 2012. PMID: 22592955 Free PMC article.
Mitotic index in Down's syndrome with and without dementia.
Jenkins EC, Ye L, Li S, Zigman WB, Schupf N, Sersen EA, Zhong N, Miezejeski CM, Brooks SS, Silverman WP. Jenkins EC, et al. Among authors: ye l. Am J Med Genet A. 2004 Mar 15;125A(3):315-7. doi: 10.1002/ajmg.a.20453. Am J Med Genet A. 2004. PMID: 14994244 No abstract available.
8,679 results