Huang M - Search Results

1

Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.

Cai YJ, Lu JJ, Zhu H, Xie H, Huang M, Lin LP, Zhang XW, Ding J. Cai YJ, et al. Among authors: huang m. Free Radic Biol Med. 2008 Sep 1;45(5):627-35. doi: 10.1016/j.freeradbiomed.2008.05.017. Epub 2008 May 28. Free Radic Biol Med. 2008. PMID: 18582559

2

DNA damage, c-myc suppression and apoptosis induced by the novel topoisomerase II inhibitor, salvicine, in human breast cancer MCF-7 cells.

Lu HR, Meng LH, Huang M, Zhu H, Miao ZH, Ding J. Lu HR, et al. Among authors: huang m. Cancer Chemother Pharmacol. 2005 Mar;55(3):286-94. doi: 10.1007/s00280-004-0877-z. Epub 2004 Nov 16. Cancer Chemother Pharmacol. 2005. PMID: 15592835

3

Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin.

Gao H, Zhang X, Chen Y, Shen H, Sun J, Huang M, Ding J, Li C, Lu W. Gao H, et al. Among authors: huang m. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2003-6. doi: 10.1016/j.bmcl.2005.02.072. Bioorg Med Chem Lett. 2005. PMID: 15808456

4

Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines.

Lu DY, Huang M, Xu CH, Yang WY, Hu CX, Lin LP, Tong LJ, Li MH, Lu W, Zhang XW, Ding J. Lu DY, et al. Among authors: huang m. BMC Pharmacol. 2005 Jun 20;5:11. doi: 10.1186/1471-2210-5-11. BMC Pharmacol. 2005. PMID: 15963241 Free PMC article.

5

Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase.

Lu HR, Zhu H, Huang M, Chen Y, Cai YJ, Miao ZH, Zhang JS, Ding J. Lu HR, et al. Among authors: huang m. Mol Pharmacol. 2005 Oct;68(4):983-94. doi: 10.1124/mol.105.011544. Epub 2005 Jul 15. Mol Pharmacol. 2005. PMID: 16024664

6

Medicinal chemistry of probimane and MST-16: comparison of anticancer effects between bisdioxopiperazines.

Lu DY, Huang M, Xu CH, Zhu H, Xu B, Ding J. Lu DY, et al. Among authors: huang m. Med Chem. 2006 Jul;2(4):369-75. doi: 10.2174/157340606777724095. Med Chem. 2006. PMID: 16848748

7

Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.

Huang M, Gao H, Chen Y, Zhu H, Cai Y, Zhang X, Miao Z, Jiang H, Zhang J, Shen H, Lin L, Lu W, Ding J. Huang M, et al. Clin Cancer Res. 2007 Feb 15;13(4):1298-307. doi: 10.1158/1078-0432.CCR-06-1277. Epub 2007 Feb 7. Clin Cancer Res. 2007. PMID: 17287296

8

R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.

Zhu H, Huang M, Yang F, Chen Y, Miao ZH, Qian XH, Xu YF, Qin YX, Luo HB, Shen X, Geng MY, Cai YJ, Ding J. Zhu H, et al. Among authors: huang m. Mol Cancer Ther. 2007 Feb;6(2):484-95. doi: 10.1158/1535-7163.MCT-06-0584. Mol Cancer Ther. 2007. PMID: 17308047

9

[Repair pathways in response to DNA double-strand breaks].

Huang M, Miao ZH, Ding J. Huang M, et al. Sheng Li Ke Xue Jin Zhan. 2007 Oct;38(4):295-300. Sheng Li Ke Xue Jin Zhan. 2007. PMID: 18232297 Review. Chinese.

10

Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.

Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J. Huang M, et al. Mol Cancer Ther. 2008 Jun;7(6):1440-9. doi: 10.1158/1535-7163.MCT-07-2116. Mol Cancer Ther. 2008. PMID: 18566216

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