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Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes.
Kulkarni-Almeida A, Suthar A, Goswami H, Vishwakarma R, Chauhan VS, Balakrishnan A, Sharma S. Kulkarni-Almeida A, et al. Among authors: vishwakarma r. Phytomedicine. 2008 Dec;15(12):1079-86. doi: 10.1016/j.phymed.2008.04.013. Epub 2008 Jun 25. Phytomedicine. 2008. PMID: 18583119
Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists.
Bharate SB, Rodge A, Joshi RK, Kaur J, Srinivasan S, Kumar SS, Kulkarni-Almeida A, Balachandran S, Balakrishnan A, Vishwakarma RA. Bharate SB, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6357-61. doi: 10.1016/j.bmcl.2008.10.085. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993064
Synthesis and biological activity of novel MIF antagonists.
Balachandran S, Gadekar PK, Parkale S, Yadav VN, Kamath D, Ramaswamy S, Sharma S, Vishwakarma RA, Dagia NM. Balachandran S, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1508-11. doi: 10.1016/j.bmcl.2010.12.127. Epub 2011 Jan 1. Bioorg Med Chem Lett. 2011. PMID: 21277206
A novel mTOR inhibitor is efficacious in a murine model of colitis.
Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM. Bhonde MR, et al. Among authors: vishwakarma ra. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18927209 Free article.
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
Balachandran S, Rodge A, Gadekar PK, Yadav VN, Kamath D, Chetrapal-Kunwar A, Bhatt P, Srinivasan S, Sharma S, Vishwakarma RA, Dagia NM. Balachandran S, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4773-6. doi: 10.1016/j.bmcl.2009.06.052. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19592246
Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667.
Kulkarni-Almeida AA, Brahma MK, Padmanabhan P, Mishra PD, Parab RR, Gaikwad NV, Thakkar CS, Tokdar P, Ranadive PV, Nair AS, Damre AA, Bahirat UA, Deshmukh NJ, Doshi LS, Dixit AV, George SD, Vishwakarma RA, Nemmani KV, Mahajan GB. Kulkarni-Almeida AA, et al. Among authors: vishwakarma ra. AMB Express. 2011 Nov 21;1(1):42. doi: 10.1186/2191-0855-1-42. AMB Express. 2011. PMID: 22104600 Free PMC article.
460 results