Simonen M - Search Results

1

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity.

Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chène P, De Pover A, Schoemaker K, Fabbro D, Gabriel D, Simonen M, Murphy L, Finan P, Sellers W, García-Echeverría C. Maira SM, et al. Among authors: simonen m. Mol Cancer Ther. 2008 Jul;7(7):1851-63. doi: 10.1158/1535-7163.MCT-08-0017. Epub 2008 Jul 7. Mol Cancer Ther. 2008. PMID: 18606717

2

Comparison of variability and sensitivity between nuclear translocation and luciferase reporter gene assays.

Unterreiner V, Ibig-Rehm Y, Simonen M, Gubler H, Gabriel D. Unterreiner V, et al. Among authors: simonen m. J Biomol Screen. 2009 Jan;14(1):59-65. doi: 10.1177/1087057108328016. J Biomol Screen. 2009. PMID: 19171921

3

High-content assay to study protein prenylation.

Simonen M, Ibig-Rehm Y, Hofmann G, Zimmermann J, Albrecht G, Magnier M, Heidinger V, Gabriel D. Simonen M, et al. J Biomol Screen. 2008 Jul;13(6):456-67. doi: 10.1177/1087057108318757. Epub 2008 May 28. J Biomol Screen. 2008. PMID: 18509097

4

Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells.

Zhang H, Cowan-Jacob SW, Simonen M, Greenhalf W, Heim J, Meyhack B. Zhang H, et al. Among authors: simonen m. J Biol Chem. 2000 Apr 14;275(15):11092-9. doi: 10.1074/jbc.275.15.11092. J Biol Chem. 2000. PMID: 10753914 Free article.

5

The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis.

Simonen M, Keller H, Heim J. Simonen M, et al. Eur J Biochem. 1997 Oct 1;249(1):85-91. doi: 10.1111/j.1432-1033.1997.t01-1-00085.x. Eur J Biochem. 1997. PMID: 9363757 Free article.

6

Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12.

Brecht K, Simonen M, Heim J. Brecht K, et al. Among authors: simonen m. Apoptosis. 2005 Oct;10(5):1043-62. doi: 10.1007/s10495-005-0617-9. Apoptosis. 2005. PMID: 16151639

7

A microarray-based, integrated approach to identify novel regulators of cancer drug response and apoptosis.

Brachat A, Pierrat B, Xynos A, Brecht K, Simonen M, Brüngger A, Heim J. Brachat A, et al. Among authors: simonen m. Oncogene. 2002 Nov 28;21(54):8361-71. doi: 10.1038/sj.onc.1206016. Oncogene. 2002. PMID: 12447701

8

SH3GLB, a new endophilin-related protein family featuring an SH3 domain.

Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J. Pierrat B, et al. Among authors: simonen m. Genomics. 2001 Jan 15;71(2):222-34. doi: 10.1006/geno.2000.6378. Genomics. 2001. PMID: 11161816

9

Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family.

Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J. Pierrat B, et al. Among authors: simonen m. Eur J Biochem. 2000 May;267(9):2680-7. doi: 10.1046/j.1432-1327.2000.01285.x. Eur J Biochem. 2000. PMID: 10785390 Free article.

10

Hematopoietic transcription factor GATA-2 promotes upregulation of alpha globin and cell death in FL5.12 cells.

Brecht K, Simonen M, Kamke M, Heim J. Brecht K, et al. Among authors: simonen m. Apoptosis. 2005 Oct;10(5):1063-78. doi: 10.1007/s10495-005-0623-y. Apoptosis. 2005. PMID: 16151640

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