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Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.
Singh R, Arlt VM, Henderson CJ, Phillips DH, Farmer PB, Gamboa da Costa G. Singh R, et al. Among authors: gamboa da costa g. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1;878(23):2155-62. doi: 10.1016/j.jchromb.2010.06.008. Epub 2010 Jun 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20598652 Free PMC article.
Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.
Arlt VM, Singh R, Stiborová M, Gamboa da Costa G, Frei E, Evans JD, Farmer PB, Wolf CR, Henderson CJ, Phillips DH. Arlt VM, et al. Among authors: gamboa da costa g. Drug Metab Dispos. 2011 Dec;39(12):2169-73. doi: 10.1124/dmd.111.041343. Epub 2011 Sep 22. Drug Metab Dispos. 2011. PMID: 21940903
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
Arlt VM, Stiborová M, Henderson CJ, Thiemann M, Frei E, Aimová D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH. Arlt VM, et al. Among authors: gamboa da costa g. Carcinogenesis. 2008 Mar;29(3):656-65. doi: 10.1093/carcin/bgn002. Epub 2008 Jan 19. Carcinogenesis. 2008. PMID: 18204078
Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.
Krais AM, Speksnijder EN, Melis JP, Singh R, Caldwell A, Gamboa da Costa G, Luijten M, Phillips DH, Arlt VM. Krais AM, et al. Among authors: gamboa da costa g. Int J Cancer. 2016 Feb 15;138(4):976-82. doi: 10.1002/ijc.29836. Epub 2015 Sep 22. Int J Cancer. 2016. PMID: 26335255 Free PMC article.
Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy.
Schmeiser HH, Nortier JL, Singh R, Gamboa da Costa G, Sennesael J, Cassuto-Viguier E, Ambrosetti D, Rorive S, Pozdzik A, Phillips DH, Stiborova M, Arlt VM. Schmeiser HH, et al. Among authors: gamboa da costa g. Int J Cancer. 2014 Jul 15;135(2):502-7. doi: 10.1002/ijc.28681. Int J Cancer. 2014. PMID: 24921086
76 results