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The Procalcitonin And Survival Study (PASS) - a randomised multi-center investigator-initiated trial to investigate whether daily measurements biomarker Procalcitonin and pro-active diagnostic and therapeutic responses to abnormal Procalcitonin levels, can improve survival in intensive care unit patients. Calculated sample size (target population): 1000 patients.
Jensen JU, Lundgren B, Hein L, Mohr T, Petersen PL, Andersen LH, Lauritsen AO, Hougaard S, Mantoni T, Bømler B, Thornberg KJ, Thormar K, Løken J, Steensen M, Carl P, Petersen JA, Tousi H, Søe-Jensen P, Bestle M, Hestad S, Andersen MH, Fjeldborg P, Larsen KM, Rossau C, Thomsen CB, Ostergaard C, Kjaer J, Grarup J, Lundgren JD. Jensen JU, et al. Among authors: thormar k. BMC Infect Dis. 2008 Jul 13;8:91. doi: 10.1186/1471-2334-8-91. BMC Infect Dis. 2008. PMID: 18620598 Free PMC article. Clinical Trial.
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial.
Jensen JU, Hein L, Lundgren B, Bestle MH, Mohr TT, Andersen MH, Thornberg KJ, Løken J, Steensen M, Fox Z, Tousi H, Søe-Jensen P, Lauritsen AØ, Strange D, Petersen PL, Reiter N, Hestad S, Thormar K, Fjeldborg P, Larsen KM, Drenck NE, Ostergaard C, Kjær J, Grarup J, Lundgren JD; Procalcitonin And Survival Study (PASS) Group. Jensen JU, et al. Among authors: thormar k. Crit Care Med. 2011 Sep;39(9):2048-58. doi: 10.1097/CCM.0b013e31821e8791. Crit Care Med. 2011. PMID: 21572328 Clinical Trial.
Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial.
Jensen JU, Hein L, Lundgren B, Bestle MH, Mohr T, Andersen MH, Thornberg KJ, Løken J, Steensen M, Fox Z, Tousi H, Søe-Jensen P, Lauritsen AØ, Strange DG, Reiter N, Thormar K, Fjeldborg PC, Larsen KM, Drenck NE, Johansen ME, Nielsen LR, Ostergaard C, Kjær J, Grarup J, Lundgren JD; Procalcitonin And Survival Study (PASS) Group. Jensen JU, et al. Among authors: thormar k. BMJ Open. 2012 Mar 11;2(2):e000635. doi: 10.1136/bmjopen-2011-000635. Print 2012. BMJ Open. 2012. PMID: 22411933 Free PMC article.
Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J; 6S Trial Group; Scandinavian Critical Care Trials Group. Perner A, et al. Among authors: thormar k. N Engl J Med. 2012 Jul 12;367(2):124-34. doi: 10.1056/NEJMoa1204242. Epub 2012 Jun 27. N Engl J Med. 2012. PMID: 22738085 Free article. Clinical Trial.
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial.
Holst LB, Haase N, Wetterslev J, Wernerman J, Aneman A, Guttormsen AB, Johansson PI, Karlsson S, Klemenzson G, Winding R, Nebrich L, Albeck C, Vang ML, Bülow HH, Elkjær JM, Nielsen JS, Kirkegaard P, Nibro H, Lindhardt A, Strange D, Thormar K, Poulsen LM, Berezowicz P, Bådstøløkken PM, Strand K, Cronhjort M, Haunstrup E, Rian O, Oldner A, Bendtsen A, Iversen S, Langva JÅ, Johansen RB, Nielsen N, Pettilä V, Reinikainen M, Keld D, Leivdal S, Breider JM, Tjäder I, Reiter N, Gøttrup U, White J, Wiis J, Andersen LH, Steensen M, Perner A. Holst LB, et al. Among authors: thormar k. Trials. 2013 May 23;14:150. doi: 10.1186/1745-6215-14-150. Trials. 2013. PMID: 23702006 Free PMC article. Clinical Trial.
The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial.
Johansen ME, Jensen JU, Bestle MH, Hein L, Lauritsen AØ, Tousi H, Larsen KM, Løken J, Mohr T, Thormar K, Johansson PI, Cozzi-Lepri A, Lundgren JD. Johansen ME, et al. Among authors: thormar k. PLoS One. 2013 Nov 28;8(11):e81477. doi: 10.1371/journal.pone.0081477. eCollection 2013. PLoS One. 2013. PMID: 24312305 Free PMC article. Clinical Trial.
Lower versus higher hemoglobin threshold for transfusion in septic shock.
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen UG, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Hjortrup PB, Müller RG, Møller MH, Steensen M, Tjäder I, Kilsand K, Odeberg-Wernerman S, Sjøbø B, Bundgaard H, Thyø MA, Lodahl D, Mærkedahl R, Albeck C, Illum D, Kruse M, Winkel P, Perner A; TRISS Trial Group; Scandinavian Critical Care Trials Group. Holst LB, et al. N Engl J Med. 2014 Oct 9;371(15):1381-91. doi: 10.1056/NEJMoa1406617. Epub 2014 Oct 1. N Engl J Med. 2014. PMID: 25270275 Free article. Clinical Trial.
Mild induced hypothermia: effects on sepsis-related coagulopathy--results from a randomized controlled trial.
Johansen ME, Jensen JU, Bestle MH, Ostrowski SR, Thormar K, Christensen H, Pedersen HP, Poulsen L, Mohr T, Kjær J, Cozzi-Lepri A, Møller K, Tønnesen E, Lundgren JD, Johansson PI. Johansen ME, et al. Among authors: thormar k. Thromb Res. 2015 Jan;135(1):175-82. doi: 10.1016/j.thromres.2014.10.028. Epub 2014 Nov 5. Thromb Res. 2015. PMID: 25466837 Clinical Trial.
Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime.
Jensen JU, Hein L, Lundgren B, Bestle MH, Mohr T, Andersen MH, Løken J, Tousi H, Søe-Jensen P, Lauritsen AØ, Strange D, Petersen JA, Thormar K, Larsen KM, Drenck NE, Helweg-Larsen J, Johansen ME, Reinholdt K, Møller JK, Olesen B, Arendrup MC, Østergaard C, Cozzi-Lepri A, Grarup J, Lundgren JD; Procalcitonin and Survival Study Group. Jensen JU, et al. Among authors: thormar k. Crit Care Med. 2015 Mar;43(3):594-602. doi: 10.1097/CCM.0000000000000746. Crit Care Med. 2015. PMID: 25493970 Clinical Trial.
Profound endothelial damage predicts impending organ failure and death in sepsis.
Johansen ME, Johansson PI, Ostrowski SR, Bestle MH, Hein L, Jensen AL, Søe-Jensen P, Andersen MH, Steensen M, Mohr T, Thormar K, Lundgren B, Cozzi-Lepri A, Lundgren JD, Jensen JU. Johansen ME, et al. Among authors: thormar k. Semin Thromb Hemost. 2015 Feb;41(1):16-25. doi: 10.1055/s-0034-1398377. Epub 2015 Jan 15. Semin Thromb Hemost. 2015. PMID: 25590523 Clinical Trial.
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