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Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Garg N, Li YL, Garcia Collazo AM, Litten C, Ryono DE, Zhang M, Caringal Y, Brigance RP, Meng W, Washburn WN, Agback P, Mellström K, Rehnmark S, Rahimi-Ghadim M, Norin T, Grynfarb M, Sandberg J, Grover G, Malm J. Garg N, et al. Among authors: rehnmark s. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4131-4. doi: 10.1016/j.bmcl.2007.05.049. Epub 2007 May 21. Bioorg Med Chem Lett. 2007. PMID: 17543524
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans.
Berkenstam A, Kristensen J, Mellström K, Carlsson B, Malm J, Rehnmark S, Garg N, Andersson CM, Rudling M, Sjöberg F, Angelin B, Baxter JD. Berkenstam A, et al. Among authors: rehnmark s. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):663-7. doi: 10.1073/pnas.0705286104. Epub 2007 Dec 26. Proc Natl Acad Sci U S A. 2008. PMID: 18160532 Free PMC article. Clinical Trial.
Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease.
Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Bárány P, Heimbürger O, Suliman ME, Alvestrand A, Lindholm B, Stenvinkel P. Carrero JJ, et al. Among authors: rehnmark s. J Intern Med. 2007 Dec;262(6):690-701. doi: 10.1111/j.1365-2796.2007.01865.x. Epub 2007 Oct 1. J Intern Med. 2007. PMID: 17908160 Free article.
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
Sanyal S, Båvner A, Haroniti A, Nilsson LM, Lundåsen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E. Sanyal S, et al. Among authors: rehnmark s. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15665-70. doi: 10.1073/pnas.0706736104. Epub 2007 Sep 25. Proc Natl Acad Sci U S A. 2007. PMID: 17895379 Free PMC article.
30 results