Wrighton SA - Search Results

1

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.

Dennison JB, Mohutsky MA, Barbuch RJ, Wrighton SA, Hall SD. Dennison JB, et al. Among authors: wrighton sa. J Pharmacol Exp Ther. 2008 Oct;327(1):248-57. doi: 10.1124/jpet.108.139998. Epub 2008 Jul 23. J Pharmacol Exp Ther. 2008. PMID: 18650247

2

Prediction of CYP3A-mediated drug-drug interactions using human hepatocytes suspended in human plasma.

Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD. Mao J, et al. Among authors: wrighton sa. Drug Metab Dispos. 2011 Apr;39(4):591-602. doi: 10.1124/dmd.110.036400. Epub 2011 Jan 6. Drug Metab Dispos. 2011. PMID: 21212240 Free article.

3

Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.

Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD. Mao J, et al. Among authors: wrighton sa. Drug Metab Dispos. 2012 Apr;40(4):706-16. doi: 10.1124/dmd.111.043158. Epub 2012 Jan 6. Drug Metab Dispos. 2012. PMID: 22228749

4

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA. Williams JA, et al. Among authors: wrighton sa. Drug Metab Dispos. 2002 Aug;30(8):883-91. doi: 10.1124/dmd.30.8.883. Drug Metab Dispos. 2002. PMID: 12124305

5

The use of a substrate cassette strategy to improve the capacity and throughput of cytochrome P450 induction studies in human hepatocytes.

Mohutsky MA, Petullo DM, Wrighton SA. Mohutsky MA, et al. Among authors: wrighton sa. Drug Metab Dispos. 2005 Jul;33(7):920-3. doi: 10.1124/dmd.105.004291. Epub 2005 Mar 31. Drug Metab Dispos. 2005. PMID: 15802386

6

Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations.

Mohutsky MA, Chien JY, Ring BJ, Wrighton SA. Mohutsky MA, et al. Among authors: wrighton sa. Pharm Res. 2006 Apr;23(4):654-62. doi: 10.1007/s11095-006-9663-4. Epub 2006 Mar 24. Pharm Res. 2006. PMID: 16550474

7

Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity.

Kolwankar D, Vuppalanchi R, Ethell B, Jones DR, Wrighton SA, Hall SD, Chalasani N. Kolwankar D, et al. Among authors: wrighton sa. Clin Gastroenterol Hepatol. 2007 Mar;5(3):388-93. doi: 10.1016/j.cgh.2006.12.021. Clin Gastroenterol Hepatol. 2007. PMID: 17368239

8

Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.

Gorski JC, Jones DR, Wrighton SA, Hall SD. Gorski JC, et al. Among authors: wrighton sa. Biochem Pharmacol. 1994 Jul 5;48(1):173-82. doi: 10.1016/0006-2952(94)90237-2. Biochem Pharmacol. 1994. PMID: 8043020

9

Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone.

Gorski JC, Jones DR, Wrighton SA, Hall SD. Gorski JC, et al. Among authors: wrighton sa. Xenobiotica. 1997 Mar;27(3):243-56. doi: 10.1080/004982597240578. Xenobiotica. 1997. PMID: 9141232

10

Autoactivation and activation of the cytochrome P450s.

Ekins S, Ring BJ, Binkley SN, Hall SD, Wrighton SA. Ekins S, et al. Among authors: wrighton sa. Int J Clin Pharmacol Ther. 1998 Dec;36(12):642-51. Int J Clin Pharmacol Ther. 1998. PMID: 9877001

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