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NAD+ auxotrophy is bacteriocidal for the tubercle bacilli.
Vilchèze C, Weinrick B, Wong KW, Chen B, Jacobs WR Jr. Vilchèze C, et al. Among authors: chen b. Mol Microbiol. 2010 Apr;76(2):365-77. doi: 10.1111/j.1365-2958.2010.07099.x. Epub 2010 Feb 28. Mol Microbiol. 2010. PMID: 20199601 Free PMC article.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, Jacobs WR Jr. Bhatt A, et al. Among authors: chen b. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5157-62. doi: 10.1073/pnas.0608654104. Epub 2007 Mar 12. Proc Natl Acad Sci U S A. 2007. PMID: 17360388 Free PMC article.
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