Harden TK - Search Results

1

Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.

Houston D, Costanzi S, Jacobson KA, Harden TK. Houston D, et al. Among authors: harden tk. Comb Chem High Throughput Screen. 2008 Jul;11(6):410-9. doi: 10.2174/138620708784911474. Comb Chem High Throughput Screen. 2008. PMID: 18673269 Free PMC article. Review.

2

Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.

Waldo GL, Corbitt J, Boyer JL, Ravi G, Kim HS, Ji XD, Lacy J, Jacobson KA, Harden TK. Waldo GL, et al. Among authors: harden tk. Mol Pharmacol. 2002 Nov;62(5):1249-57. doi: 10.1124/mol.62.5.1249. Mol Pharmacol. 2002. PMID: 12391289 Free PMC article.

3

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.

Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. Chhatriwala M, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. doi: 10.1124/jpet.104.068650. Epub 2004 Sep 2. J Pharmacol Exp Ther. 2004. PMID: 15345752 Free PMC article.

4

[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.

Houston D, Ohno M, Nicholas RA, Jacobson KA, Harden TK. Houston D, et al. Among authors: harden tk. Br J Pharmacol. 2006 Mar;147(5):459-67. doi: 10.1038/sj.bjp.0706453. Br J Pharmacol. 2006. PMID: 16299552 Free PMC article.

5

UDP is a competitive antagonist at the human P2Y14 receptor.

Fricks IP, Maddileti S, Carter RL, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. Fricks IP, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2008 May;325(2):588-94. doi: 10.1124/jpet.108.136309. Epub 2008 Feb 5. J Pharmacol Exp Ther. 2008. PMID: 18252808 Free PMC article.

6

A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK. Barrett MO, et al. Among authors: harden tk. Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16. Mol Pharmacol. 2013. PMID: 23592514 Free PMC article.

7

2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.

Boyer JL, Adams M, Ravi RG, Jacobson KA, Harden TK. Boyer JL, et al. Among authors: harden tk. Br J Pharmacol. 2002 Apr;135(8):2004-10. doi: 10.1038/sj.bjp.0704673. Br J Pharmacol. 2002. PMID: 11959804 Free PMC article.

8

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.

Boyer JL, Mohanram A, Camaioni E, Jacobson KA, Harden TK. Boyer JL, et al. Among authors: harden tk. Br J Pharmacol. 1998 May;124(1):1-3. doi: 10.1038/sj.bjp.0701837. Br J Pharmacol. 1998. PMID: 9630335 Free PMC article.

9

(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.

Bourdon DM, Mahanty SK, Jacobson KA, Boyer JL, Harden TK. Bourdon DM, et al. Among authors: harden tk. J Thromb Haemost. 2006 Apr;4(4):861-8. doi: 10.1111/j.1538-7836.2006.01866.x. J Thromb Haemost. 2006. PMID: 16634757 Free PMC article.

10

2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.

Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA. Kim HS, et al. Among authors: harden tk. J Med Chem. 2003 Nov 6;46(23):4974-87. doi: 10.1021/jm030127+. J Med Chem. 2003. PMID: 14584948 Free PMC article.

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