Kearns JD - Search Results

1

Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.

Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, Hoffmann A. Werner SL, et al. Among authors: kearns jd. Genes Dev. 2008 Aug 1;22(15):2093-101. doi: 10.1101/gad.1680708. Genes Dev. 2008. PMID: 18676814 Free PMC article.

2

IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression.

Kearns JD, Basak S, Werner SL, Huang CS, Hoffmann A. Kearns JD, et al. J Cell Biol. 2006 Jun 5;173(5):659-64. doi: 10.1083/jcb.200510155. Epub 2006 May 30. J Cell Biol. 2006. PMID: 16735576 Free PMC article.

3

A fourth IkappaB protein within the NF-kappaB signaling module.

Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. Basak S, et al. Among authors: kearns jd. Cell. 2007 Jan 26;128(2):369-81. doi: 10.1016/j.cell.2006.12.033. Cell. 2007. PMID: 17254973 Free PMC article.

4

A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.

O'Dea EL, Barken D, Peralta RQ, Tran KT, Werner SL, Kearns JD, Levchenko A, Hoffmann A. O'Dea EL, et al. Among authors: kearns jd. Mol Syst Biol. 2007;3:111. doi: 10.1038/msb4100148. Epub 2007 May 8. Mol Syst Biol. 2007. PMID: 17486138 Free PMC article.

5

UV as an amplifier rather than inducer of NF-kappaB activity.

O'Dea EL, Kearns JD, Hoffmann A. O'Dea EL, et al. Among authors: kearns jd. Mol Cell. 2008 Jun 6;30(5):632-41. doi: 10.1016/j.molcel.2008.03.017. Mol Cell. 2008. PMID: 18538661 Free PMC article.

6

Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling.

Kearns JD, Hoffmann A. Kearns JD, et al. J Biol Chem. 2009 Feb 27;284(9):5439-43. doi: 10.1074/jbc.R800008200. Epub 2008 Oct 20. J Biol Chem. 2009. PMID: 18940809 Free PMC article. Review. No abstract available.

7

Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity.

Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. Shih VF, et al. Among authors: kearns jd. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9619-24. doi: 10.1073/pnas.0812367106. Epub 2009 Jun 1. Proc Natl Acad Sci U S A. 2009. PMID: 19487661 Free PMC article.

8

Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module.

Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. Longo DM, et al. Among authors: kearns jd. PLoS Comput Biol. 2013;9(6):e1003112. doi: 10.1371/journal.pcbi.1003112. Epub 2013 Jun 27. PLoS Comput Biol. 2013. PMID: 23825938 Free PMC article.

9

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.

Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. Tsui R, et al. Among authors: kearns jd. Nat Commun. 2015 May 7;6:7068. doi: 10.1038/ncomms8068. Nat Commun. 2015. PMID: 25946967 Free PMC article.

10

Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression".

Barken D, Wang CJ, Kearns J, Cheong R, Hoffmann A, Levchenko A. Barken D, et al. Science. 2005 Apr 1;308(5718):52; author reply 52. doi: 10.1126/science.1108198. Science. 2005. PMID: 15802586 Free PMC article. No abstract available.

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