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19 results

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Page 1
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, Lenz O, Delouvroy F, Pille G, Surleraux D, Wigerinck P, Samuelsson B, Simmen K. Raboisson P, et al. Among authors: hamelink e. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8. doi: 10.1016/j.bmcl.2008.07.088. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18678486
Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.
Bäck M, Johansson PO, Wångsell F, Thorstensson F, Kvarnström I, Ayesa S, Wähling H, Pelcman M, Jansson K, Lindström S, Wallberg H, Classon B, Rydergård C, Vrang L, Hamelink E, Hallberg A, Rosenquist S, Samuelsson B. Bäck M, et al. Among authors: hamelink e. Bioorg Med Chem. 2007 Nov 15;15(22):7184-202. doi: 10.1016/j.bmc.2007.07.027. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17845856
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Nilsson M, Belfrage AK, Lindström S, Wähling H, Lindquist C, Ayesa S, Kahnberg P, Pelcman M, Benkestock K, Agback T, Vrang L, Terelius Y, Wikström K, Hamelink E, Rydergård C, Edlund M, Eneroth A, Raboisson P, Lin TI, de Kock H, Wigerinck P, Simmen K, Samuelsson B, Rosenquist S. Nilsson M, et al. Among authors: hamelink e. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4004-11. doi: 10.1016/j.bmcl.2010.05.029. Epub 2010 May 21. Bioorg Med Chem Lett. 2010. PMID: 20541405
New inhibitors of the malaria aspartyl proteases plasmepsin I and II.
Dahlgren A, Kvarnström I, Vrang L, Hamelink E, Hallberg A, Rosenquist A, Samuelsson B. Dahlgren A, et al. Among authors: hamelink e. Bioorg Med Chem. 2003 Aug 5;11(16):3423-37. doi: 10.1016/s0968-0896(03)00312-2. Bioorg Med Chem. 2003. PMID: 12878137
Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-L-hydroxyproline bioisostere.
Thorstensson F, Wångsell F, Kvarnström I, Vrang L, Hamelink E, Jansson K, Hallberg A, Rosenquist S, Samuelsson B. Thorstensson F, et al. Among authors: hamelink e. Bioorg Med Chem. 2007 Jan 15;15(2):827-38. doi: 10.1016/j.bmc.2006.10.044. Epub 2006 Oct 25. Bioorg Med Chem. 2007. PMID: 17107807
New potent C2-symmetric malaria plasmepsin I and II inhibitors.
Oscarsson K, Oscarson S, Vrang L, Hamelink E, Hallberg A, Samuelsson B. Oscarsson K, et al. Among authors: hamelink e. Bioorg Med Chem. 2003 Apr 3;11(7):1235-46. doi: 10.1016/s0968-0896(02)00643-0. Bioorg Med Chem. 2003. PMID: 12628651
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