Onda M - Search Results

1

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes.

Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I. Onda M, et al. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6. doi: 10.1073/pnas.0804851105. Epub 2008 Aug 4. Proc Natl Acad Sci U S A. 2008. PMID: 18678888 Free PMC article.

2

A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.

Bera TK, Onda M, Brinkmann U, Pastan I. Bera TK, et al. Among authors: onda m. J Mol Biol. 1998 Aug 21;281(3):475-83. doi: 10.1006/jmbi.1998.1948. J Mol Biol. 1998. PMID: 9698563

3

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point.

Onda M, Kreitman RJ, Vasmatzis G, Lee B, Pastan I. Onda M, et al. J Immunol. 1999 Dec 1;163(11):6072-7. J Immunol. 1999. PMID: 10570296

4

Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.

Tsutsumi Y, Onda M, Nagata S, Lee B, Kreitman RJ, Pastan I. Tsutsumi Y, et al. Among authors: onda m. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8548-53. doi: 10.1073/pnas.140210597. Proc Natl Acad Sci U S A. 2000. PMID: 10890891 Free PMC article.

5

Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2.

Onda M, Willingham M, Wang QC, Kreitman RJ, Tsutsumi Y, Nagata S, Pastan I. Onda M, et al. J Immunol. 2000 Dec 15;165(12):7150-6. doi: 10.4049/jimmunol.165.12.7150. J Immunol. 2000. PMID: 11120846

6

Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A.

Onda M, Olafsen T, Tsutsumi Y, Bruland OS, Pastan I. Onda M, et al. J Immunother. 2001 Mar-Apr;24(2):144-50. J Immunother. 2001. PMID: 11265772

7

Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.

Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I. Onda M, et al. Cancer Res. 2001 Jul 1;61(13):5070-7. Cancer Res. 2001. PMID: 11431343

8

Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A.

Onda M, Olafsen T, Tsutsumi Y, Bruland ØS ØS, Pastan I. Onda M, et al. J Immunother (1991). 2001 Mar;24(2):144-150. J Immunother (1991). 2001. PMID: 11449071

9

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments.

Nagata S, Onda M, Numata Y, Santora K, Beers R, Kreitman RJ, Pastan I. Nagata S, et al. Among authors: onda m. Clin Cancer Res. 2002 Jul;8(7):2345-55. Clin Cancer Res. 2002. PMID: 12114439

10

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.

Fan D, Yano S, Shinohara H, Solorzano C, Van Arsdall M, Bucana CD, Pathak S, Kruzel E, Herbst RS, Onn A, Roach JS, Onda M, Wang QC, Pastan I, Fidler IJ. Fan D, et al. Among authors: onda m. Mol Cancer Ther. 2002 Jun;1(8):595-600. Mol Cancer Ther. 2002. PMID: 12479219

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