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Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
Herbert AP, Deakin JA, Schmidt CQ, Blaum BS, Egan C, Ferreira VP, Pangburn MK, Lyon M, Uhrín D, Barlow PN. Herbert AP, et al. Among authors: schmidt cq. J Biol Chem. 2007 Jun 29;282(26):18960-8. doi: 10.1074/jbc.M609636200. Epub 2007 Mar 13. J Biol Chem. 2007. PMID: 17360715 Free article.
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
Moore I, Strain L, Pappworth I, Kavanagh D, Barlow PN, Herbert AP, Schmidt CQ, Staniforth SJ, Holmes LV, Ward R, Morgan L, Goodship TH, Marchbank KJ. Moore I, et al. Among authors: schmidt cq. Blood. 2010 Jan 14;115(2):379-87. doi: 10.1182/blood-2009-05-221549. Epub 2009 Oct 27. Blood. 2010. PMID: 19861685 Free PMC article.
Complement factor h autoantibodies and age-related macular degeneration.
Dhillon B, Wright AF, Tufail A, Pappworth I, Hayward C, Moore I, Strain L, Kavanagh D, Barlow PN, Herbert AP, Schmidt CQ, Armbrecht AM, Laude A, Deary IJ, Staniforth SJ, Holmes LV, Goodship TH, Marchbank KJ. Dhillon B, et al. Among authors: schmidt cq. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5858-63. doi: 10.1167/iovs.09-5124. Epub 2010 Jun 30. Invest Ophthalmol Vis Sci. 2010. PMID: 20592223
Structural basis for engagement by complement factor H of C3b on a self surface.
Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP. Morgan HP, et al. Among authors: schmidt cq. Nat Struct Mol Biol. 2011 Apr;18(4):463-70. doi: 10.1038/nsmb.2018. Epub 2011 Feb 13. Nat Struct Mol Biol. 2011. PMID: 21317894 Free PMC article.
74 results