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Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.
Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: andersen b. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090
Iminosugars: potential inhibitors of liver glycogen phosphorylase.
Jakobsen P, Lundbeck JM, Kristiansen M, Breinholt J, Demuth H, Pawlas J, Candela MP, Andersen B, Westergaard N, Lundgren K, Asano N. Jakobsen P, et al. Among authors: andersen b. Bioorg Med Chem. 2001 Mar;9(3):733-44. doi: 10.1016/s0968-0896(00)00291-1. Bioorg Med Chem. 2001. PMID: 11310609
Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Madsen P, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J. Madsen P, et al. Among authors: andersen b. J Med Chem. 2002 Dec 19;45(26):5755-75. doi: 10.1021/jm0208572. J Med Chem. 2002. PMID: 12477359
1,540 results