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Reply to: Antibiotics and hexagonal order in the bacterial outer membrane.
Manioglu S, Modaresi SM, Thoma J, Overall SA, Upert G, Luther A, Barnes AB, Obrecht D, Müller DJ, Hiller S. Manioglu S, et al. Among authors: upert g. Nat Commun. 2023 Aug 9;14(1):4773. doi: 10.1038/s41467-023-40276-z. Nat Commun. 2023. PMID: 37558675 Free PMC article. No abstract available.
Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae.
Schuster M, Brabet E, Oi KK, Desjonquères N, Moehle K, Le Poupon K, Hell S, Gable S, Rithié V, Dillinger S, Zbinden P, Luther A, Li C, Stiegeler S, D'Arco C, Locher H, Remus T, DiMaio S, Motta P, Wach A, Jung F, Upert G, Obrecht D, Benghezal M, Zerbe O. Schuster M, et al. Among authors: upert g. Sci Adv. 2023 May 24;9(21):eadg3683. doi: 10.1126/sciadv.adg3683. Epub 2023 May 24. Sci Adv. 2023. PMID: 37224246 Free PMC article.
From a Cone Snail Toxin to a Competitive MC4R Antagonist.
Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N. Reynaud S, et al. Among authors: upert g. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5. J Med Chem. 2022. PMID: 36063022
A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.
Droctové L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, Gouin C, Lancien M, Stanajic-Petrovic G, Braco L, Blanchet G, Upert G, De Pauw G, Barbe P, Keck M, Mourier G, Mouillac B, Denis S, Rodríguez de la Vega RC, Quinton L, Gilles N. Droctové L, et al. Among authors: upert g. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28. Br J Pharmacol. 2022. PMID: 35122240 Free article.
Emerging peptide antibiotics with therapeutic potential.
Upert G, Luther A, Obrecht D, Ermert P. Upert G, et al. Med Drug Discov. 2021 Mar;9:100078. doi: 10.1016/j.medidd.2020.100078. Epub 2020 Dec 30. Med Drug Discov. 2021. PMID: 33398258 Free PMC article. Review.
A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N. Reynaud S, et al. Among authors: upert g. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32602722
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