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Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.
Ochong E, Bell DJ, Johnson DJ, D'Alessandro U, Mulenga M, Muangnoicharoen S, Van Geertruyden JP, Winstanley PA, Bray PG, Ward SA, Owen A. Ochong E, et al. Among authors: johnson dj. Antimicrob Agents Chemother. 2008 Nov;52(11):3883-8. doi: 10.1128/AAC.00431-08. Epub 2008 Aug 25. Antimicrob Agents Chemother. 2008. PMID: 18725445 Free PMC article.
Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa.
Alker AP, Juliano JJ, Meshnick SR, Owen A, Ochong E, Bell DJ, Johnson DJ, d'Alessandro U, Mulenga M, Muangnoicharoen S, Van Geertruyden JP, Winstanley PA, Bray PG, Ward SA. Alker AP, et al. Among authors: johnson dj. Antimicrob Agents Chemother. 2009 Apr;53(4):1722; author reply 1722-3. doi: 10.1128/AAC.01427-08. Antimicrob Agents Chemother. 2009. PMID: 19299520 Free PMC article. No abstract available.
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Bray PG, Mungthin M, Hastings IM, Biagini GA, Saidu DK, Lakshmanan V, Johnson DJ, Hughes RH, Stocks PA, O'Neill PM, Fidock DA, Warhurst DC, Ward SA. Bray PG, et al. Among authors: johnson dj. Mol Microbiol. 2006 Oct;62(1):238-51. doi: 10.1111/j.1365-2958.2006.05368.x. Epub 2006 Aug 31. Mol Microbiol. 2006. PMID: 16956382 Free PMC article.
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
Fisher N, Abd Majid R, Antoine T, Al-Helal M, Warman AJ, Johnson DJ, Lawrenson AS, Ranson H, O'Neill PM, Ward SA, Biagini GA. Fisher N, et al. Among authors: johnson dj. J Biol Chem. 2012 Mar 23;287(13):9731-9741. doi: 10.1074/jbc.M111.324319. Epub 2012 Jan 26. J Biol Chem. 2012. PMID: 22282497 Free PMC article.
407 results