DeFeo-Jones D - Search Results

1

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. She QB, et al. Among authors: defeo jones d. PLoS One. 2008 Aug 26;3(8):e3065. doi: 10.1371/journal.pone.0003065. PLoS One. 2008. PMID: 18725974 Free PMC article.

2

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members.

DeFeo-Jones D, Barnett SF, Fu S, Hancock PJ, Haskell KM, Leander KR, McAvoy E, Robinson RG, Duggan ME, Lindsley CW, Zhao Z, Huber HE, Jones RE. DeFeo-Jones D, et al. Mol Cancer Ther. 2005 Feb;4(2):271-9. Mol Cancer Ther. 2005. PMID: 15713898

3

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo.

Cherrin C, Haskell K, Howell B, Jones R, Leander K, Robinson R, Watkins A, Bilodeau M, Hoffman J, Sanderson P, Hartman G, Mahan E, Prueksaritanont T, Jiang G, She QB, Rosen N, Sepp-Lorenzino L, Defeo-Jones D, Huber HE. Cherrin C, et al. Among authors: defeo jones d. Cancer Biol Ther. 2010 Apr 1;9(7):493-503. doi: 10.4161/cbt.9.7.11100. Epub 2010 Apr 1. Cancer Biol Ther. 2010. PMID: 20139722 Free PMC article.

4

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.

Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM, Nahas DD, Robinson RG, Huber HE. Barnett SF, et al. Biochem J. 2005 Jan 15;385(Pt 2):399-408. doi: 10.1042/BJ20041140. Biochem J. 2005. PMID: 15456405 Free PMC article.

5

Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

Bilodeau MT, Balitza AE, Hoffman JM, Manley PJ, Barnett SF, Defeo-Jones D, Haskell K, Jones RE, Leander K, Robinson RG, Smith AM, Huber HE, Hartman GD. Bilodeau MT, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3178-82. doi: 10.1016/j.bmcl.2008.04.074. Epub 2008 May 1. Bioorg Med Chem Lett. 2008. PMID: 18479914

6

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Lindsley CW, Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME. Lindsley CW, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. doi: 10.1016/j.bmcl.2004.11.011. Bioorg Med Chem Lett. 2005. PMID: 15664853

7

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.

Hartnett JC, Barnett SF, Bilodeau MT, Defeo-Jones D, Hartman GD, Huber HE, Jones RE, Kral AM, Robinson RG, Wu Z. Hartnett JC, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2194-7. doi: 10.1016/j.bmcl.2007.12.040. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18294842

8

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo.

DeFeo-Jones D, Garsky VM, Wong BK, Feng DM, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Wai J, Senderak ET, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Freidinger R, Huff J, Oliff A, Jones RE. DeFeo-Jones D, et al. Nat Med. 2000 Nov;6(11):1248-52. doi: 10.1038/81351. Nat Med. 2000. PMID: 11062536

9

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.

Zhao Z, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huber HE, Duggan ME, Lindsley CW. Zhao Z, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. doi: 10.1016/j.bmcl.2007.11.015. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18054229

10

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

Li Y, Liang J, Siu T, Hu E, Rossi MA, Barnett SF, Defeo-Jones D, Jones RE, Robinson RG, Leander K, Huber HE, Mittal S, Cosford N, Prasit P. Li Y, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2009 Feb 1;19(3):834-6. doi: 10.1016/j.bmcl.2008.12.017. Epub 2008 Dec 7. Bioorg Med Chem Lett. 2009. PMID: 19097777

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