Ye Q - Search Results

1

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. She QB, et al. Among authors: ye q. PLoS One. 2008 Aug 26;3(8):e3065. doi: 10.1371/journal.pone.0003065. PLoS One. 2008. PMID: 18725974 Free PMC article.

2

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells.

She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. She QB, et al. Among authors: ye q. Cancer Cell. 2005 Oct;8(4):287-97. doi: 10.1016/j.ccr.2005.09.006. Cancer Cell. 2005. PMID: 16226704 Free PMC article.

3

BRAF mutation predicts sensitivity to MEK inhibition.

Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Solit DB, et al. Among authors: ye q. Nature. 2006 Jan 19;439(7074):358-62. doi: 10.1038/nature04304. Epub 2005 Nov 6. Nature. 2006. PMID: 16273091 Free PMC article.

4

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers.

Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, Solit DB. Chandarlapaty S, et al. Among authors: ye q. Clin Cancer Res. 2008 Jan 1;14(1):240-8. doi: 10.1158/1078-0432.CCR-07-1667. Clin Cancer Res. 2008. PMID: 18172276 Free PMC article.

5

Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.

Sawai A, Chandarlapaty S, Greulich H, Gonen M, Ye Q, Arteaga CL, Sellers W, Rosen N, Solit DB. Sawai A, et al. Among authors: ye q. Cancer Res. 2008 Jan 15;68(2):589-96. doi: 10.1158/0008-5472.CAN-07-1570. Cancer Res. 2008. PMID: 18199556 Free PMC article.

6

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N. Pratilas CA, et al. Among authors: ye q. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4519-24. doi: 10.1073/pnas.0900780106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251651 Free PMC article.

7

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.

She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, Solit DB, Rosen N. She QB, et al. Among authors: ye q. Cancer Cell. 2010 Jul 13;18(1):39-51. doi: 10.1016/j.ccr.2010.05.023. Cancer Cell. 2010. PMID: 20609351 Free PMC article.

8

PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling.

Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. Halilovic E, et al. Among authors: ye q. Cancer Res. 2010 Sep 1;70(17):6804-14. doi: 10.1158/0008-5472.CAN-10-0409. Epub 2010 Aug 10. Cancer Res. 2010. PMID: 20699365 Free PMC article.

9

A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors.

Iyer G, Morris MJ, Rathkopf D, Slovin SF, Steers M, Larson SM, Schwartz LH, Curley T, DeLaCruz A, Ye Q, Heller G, Egorin MJ, Ivy SP, Rosen N, Scher HI, Solit DB. Iyer G, et al. Among authors: ye q. Cancer Chemother Pharmacol. 2012 Apr;69(4):1089-97. doi: 10.1007/s00280-011-1789-3. Epub 2011 Nov 29. Cancer Chemother Pharmacol. 2012. PMID: 22124669 Free PMC article. Clinical Trial.

10

A diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis.

Zhang Y, Wang X, Sunkara M, Ye Q, Ponomereva LV, She QB, Morris AJ, Thorson JS. Zhang Y, et al. Among authors: ye q. Org Lett. 2013 Nov 1;15(21):5566-9. doi: 10.1021/ol4027649. Epub 2013 Oct 23. Org Lett. 2013. PMID: 24151973 Free PMC article.

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