Edler MC - Search Results

1

Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

Shin Y, Fournier JH, Brückner A, Madiraju C, Balachandran R, Raccor BS, Edler MC, Hamel E, Sikorski RP, Vogt A, Day BW, Curran DP. Shin Y, et al. Among authors: edler mc. Tetrahedron. 2007 Aug 27;63(35):8537-8562. doi: 10.1016/j.tet.2007.05.033. Tetrahedron. 2007. PMID: 18728696 Free PMC article.

2

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin.

Shin Y, Fournier JH, Balachandran R, Madiraju C, Raccor BS, Zhu G, Edler MC, Hamel E, Day BW, Curran DP. Shin Y, et al. Among authors: edler mc. Org Lett. 2005 Jul 7;7(14):2873-6. doi: 10.1021/ol050808u. Org Lett. 2005. PMID: 15987158

3

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW. Madiraju C, et al. Among authors: edler mc. Biochemistry. 2005 Nov 15;44(45):15053-63. doi: 10.1021/bi050685l. Biochemistry. 2005. PMID: 16274252

4

Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.

Kong Y, Grembecka J, Edler MC, Hamel E, Mooberry SL, Sabat M, Rieger J, Brown ML. Kong Y, et al. Among authors: edler mc. Chem Biol. 2005 Sep;12(9):1007-14. doi: 10.1016/j.chembiol.2005.06.016. Chem Biol. 2005. PMID: 16183025

5

A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp.

Chevallier C, Richardson AD, Edler MC, Hamel E, Harper MK, Ireland CM. Chevallier C, et al. Among authors: edler mc. Org Lett. 2003 Oct 2;5(20):3737-9. doi: 10.1021/ol035476c. Org Lett. 2003. PMID: 14507218

6

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Buey RM, et al. Among authors: edler mc. Nat Chem Biol. 2007 Feb;3(2):117-25. doi: 10.1038/nchembio853. Epub 2007 Jan 7. Nat Chem Biol. 2007. PMID: 17206139 Free article.

7

Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.

Edler MC, Yang G, Katherine Jung M, Bai R, Bornmann WG, Hamel E. Edler MC, et al. Arch Biochem Biophys. 2009 Jul 15;487(2):98-104. doi: 10.1016/j.abb.2009.05.014. Epub 2009 Jun 2. Arch Biochem Biophys. 2009. PMID: 19497297 Free PMC article.

8

A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.

Kong Y, Wang K, Edler MC, Hamel E, Mooberry SL, Paige MA, Brown ML. Kong Y, et al. Among authors: edler mc. Bioorg Med Chem. 2010 Jan 15;18(2):971-7. doi: 10.1016/j.bmc.2009.11.003. Epub 2009 Nov 10. Bioorg Med Chem. 2010. PMID: 20006519 Free PMC article.

9

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Edler MC, et al. Biochemistry. 2005 Aug 30;44(34):11525-38. doi: 10.1021/bi050660m. Biochemistry. 2005. PMID: 16114889

10

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, Silvestri R. La Regina G, et al. Among authors: edler mc. J Med Chem. 2007 Jun 14;50(12):2865-74. doi: 10.1021/jm061479u. Epub 2007 May 12. J Med Chem. 2007. PMID: 17497841

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