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Page 1
1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ. Guo Q, et al. Among authors: wustrow dj. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5027-31. doi: 10.1016/j.bmcl.2008.08.014. Epub 2008 Aug 9. Bioorg Med Chem Lett. 2008. PMID: 18752949
Aminopyrazine CB1 receptor inverse agonists.
Wustrow DJ, Maynard GD, Yuan J, Zhao H, Mao J, Guo Q, Kershaw M, Hammer J, Brodbeck RM, Near KE, Zhou D, Beers DS, Chenard BL, Krause JE, Hutchison AJ. Wustrow DJ, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3376-81. doi: 10.1016/j.bmcl.2008.04.022. Epub 2008 Apr 13. Bioorg Med Chem Lett. 2008. PMID: 18448340
Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, Yuan J, Sun SH, Ochoa R, Krause JE, Wustrow DJ, Cortright DN. Broom DC, et al. Among authors: wustrow dj. J Pharmacol Exp Ther. 2008 Dec;327(3):620-33. doi: 10.1124/jpet.108.141853. Epub 2008 Sep 4. J Pharmacol Exp Ther. 2008. PMID: 18772321
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.
Wustrow DJ, Capiris T, Rubin R, Knobelsdorf JA, Akunne H, Davis MD, MacKenzie R, Pugsley TA, Zoski KT, Heffner TG, Wise LD. Wustrow DJ, et al. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2067-70. doi: 10.1016/s0960-894x(98)00372-2. Bioorg Med Chem Lett. 1998. PMID: 9873487
Carboxylate bioisosteres of gabapentin.
Burgos-Lepley CE, Thompson LR, Kneen CO, Osborne SA, Bryans JS, Capiris T, Suman-Chauhan N, Dooley DJ, Donovan CM, Field MJ, Vartanian MG, Kinsora JJ, Lotarski SM, El-Kattan A, Walters K, Cherukury M, Taylor CP, Wustrow DJ, Schwarz JB. Burgos-Lepley CE, et al. Among authors: wustrow dj. Bioorg Med Chem Lett. 2006 May 1;16(9):2333-6. doi: 10.1016/j.bmcl.2005.05.016. Epub 2005 Jun 8. Bioorg Med Chem Lett. 2006. PMID: 15946842
Carboxylate bioisosteres of pregabalin.
Schwarz JB, Colbry NL, Zhu Z, Nichelson B, Barta NS, Lin K, Hudack RA, Gibbons SE, Galatsis P, DeOrazio RJ, Manning DD, Vartanian MG, Kinsora JJ, Lotarski SM, Li Z, Dickerson MR, El-Kattan A, Thorpe AJ, Donevan SD, Taylor CP, Wustrow DJ. Schwarz JB, et al. Among authors: wustrow dj. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3559-63. doi: 10.1016/j.bmcl.2006.03.083. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621528
Heteroaromatic side-chain analogs of pregabalin.
Schelkun RM, Yuen PW, Wustrow DJ, Kinsora J, Su TZ, Vartanian MG. Schelkun RM, et al. Among authors: wustrow dj. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. doi: 10.1016/j.bmcl.2005.06.090. Epub 2005 Aug 15. Bioorg Med Chem Lett. 2006. PMID: 16099652
Discovery of a novel potent GABA(B) receptor agonist.
Xu F, Peng G, Phan T, Dilip U, Chen JL, Chernov-Rogan T, Zhang X, Grindstaff K, Annamalai T, Koller K, Gallop MA, Wustrow DJ. Xu F, et al. Among authors: wustrow dj. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6582-5. doi: 10.1016/j.bmcl.2011.08.006. Epub 2011 Aug 17. Bioorg Med Chem Lett. 2011. PMID: 21920749
42 results