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Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity.
Ferry G, Tellier E, Try A, Grés S, Naime I, Simon MF, Rodriguez M, Boucher J, Tack I, Gesta S, Chomarat P, Dieu M, Raes M, Galizzi JP, Valet P, Boutin JA, Saulnier-Blache JS. Ferry G, et al. J Biol Chem. 2003 May 16;278(20):18162-9. doi: 10.1074/jbc.M301158200. Epub 2003 Mar 17. J Biol Chem. 2003. PMID: 12642576 Free PMC article.
Lysophosphatidic acid-1-receptor targeting agents for fibrosis.
Rancoule C, Pradère JP, Gonzalez J, Klein J, Valet P, Bascands JL, Schanstra JP, Saulnier-Blache JS. Rancoule C, et al. Expert Opin Investig Drugs. 2011 May;20(5):657-67. doi: 10.1517/13543784.2011.566864. Epub 2011 Mar 24. Expert Opin Investig Drugs. 2011. PMID: 21434838 Review.
Lysophosphatidic acid and renal fibrosis.
Pradère JP, Gonzalez J, Klein J, Valet P, Grès S, Salant D, Bascands JL, Saulnier-Blache JS, Schanstra JP. Pradère JP, et al. Biochim Biophys Acta. 2008 Sep;1781(9):582-7. doi: 10.1016/j.bbalip.2008.04.001. Epub 2008 Apr 11. Biochim Biophys Acta. 2008. PMID: 18455518 Free PMC article. Review.
LPA1 receptor activation promotes renal interstitial fibrosis.
Pradère JP, Klein J, Grès S, Guigné C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP. Pradère JP, et al. J Am Soc Nephrol. 2007 Dec;18(12):3110-8. doi: 10.1681/ASN.2007020196. Epub 2007 Nov 14. J Am Soc Nephrol. 2007. PMID: 18003779
Autotaxin protects microglial cells against oxidative stress.
Awada R, Rondeau P, Grès S, Saulnier-Blache JS, Lefebvre d'Hellencourt C, Bourdon E. Awada R, et al. Free Radic Biol Med. 2012 Jan 15;52(2):516-26. doi: 10.1016/j.freeradbiomed.2011.11.014. Epub 2011 Dec 8. Free Radic Biol Med. 2012. PMID: 22155714
100 results