Otani Y - Search Results

1

Design, synthesis and characterization of podocarpate derivatives as openers of BK channels.

Cui YM, Yasutomi E, Otani Y, Yoshinaga T, Ido K, Sawada K, Ohwada T. Cui YM, et al. Among authors: otani y. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5197-200. doi: 10.1016/j.bmcl.2008.08.081. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18789683

2

Generation of functionalized asymmetric benzynes with TMP-zincates. Effects of ligands on selectivity and reactivity of zincates.

Uchiyama M, Miyoshi T, Kajihara Y, Sakamoto T, Otani Y, Ohwada T, Kondo Y. Uchiyama M, et al. Among authors: otani y. J Am Chem Soc. 2002 Jul 24;124(29):8514-5. doi: 10.1021/ja0202199. J Am Chem Soc. 2002. PMID: 12121077

3

An evaluation of amide group planarity in 7-azabicyclo[2.2.1]heptane amides. Low amide bond rotation barrier in solution.

Otani Y, Nagae O, Naruse Y, Inagaki S, Ohno M, Yamaguchi K, Yamamoto G, Uchiyama M, Ohwada T. Otani Y, et al. J Am Chem Soc. 2003 Dec 10;125(49):15191-9. doi: 10.1021/ja036644z. J Am Chem Soc. 2003. PMID: 14653754

4

Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C.

Cui YM, Yasutomi E, Otani Y, Yoshinaga T, Ido K, Sawada K, Ohwada T. Cui YM, et al. Among authors: otani y. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5201-5. doi: 10.1016/j.bmcl.2008.08.078. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18789860

5

Nonplanar structures of thioamides derived from 7-azabicyclo[2.2.1]heptane. Electronically tunable planarity of thioamides.

Hori T, Otani Y, Kawahata M, Yamaguchi K, Ohwada T. Hori T, et al. Among authors: otani y. J Org Chem. 2008 Nov 21;73(22):9102-8. doi: 10.1021/jo801996b. Epub 2008 Oct 24. J Org Chem. 2008. PMID: 18947252

6

Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.

Cui YM, Yasutomi E, Otani Y, Yoshinaga T, Ido K, Sawada K, Kawahata M, Yamaguchi K, Ohwada T. Cui YM, et al. Among authors: otani y. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6386-9. doi: 10.1016/j.bmcl.2008.10.078. Epub 2008 Oct 22. Bioorg Med Chem Lett. 2008. PMID: 18990575

7

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.

Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T. Iwashita M, et al. Among authors: otani y. J Med Chem. 2009 Oct 8;52(19):5837-63. doi: 10.1021/jm900598m. J Med Chem. 2009. PMID: 19743861

8

Cyclization of arylacetoacetates to indene and dihydronaphthalene derivatives in strong acids. Evidence for involvement of further protonation of O,O-diprotonated beta-ketoester, leading to enhancement of cyclization.

Kurouchi H, Sugimoto H, Otani Y, Ohwada T. Kurouchi H, et al. Among authors: otani y. J Am Chem Soc. 2010 Jan 20;132(2):807-15. doi: 10.1021/ja908749u. J Am Chem Soc. 2010. PMID: 20017483

9

Water-stable helical structure of tertiary amides of bicyclic β-amino acid bearing 7-azabicyclo[2.2.1]heptane. Full control of amide cis-trans equilibrium by bridgehead substitution.

Hosoya M, Otani Y, Kawahata M, Yamaguchi K, Ohwada T. Hosoya M, et al. Among authors: otani y. J Am Chem Soc. 2010 Oct 27;132(42):14780-9. doi: 10.1021/ja1017877. J Am Chem Soc. 2010. PMID: 20882981

10

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives.

Cui YM, Yasutomi E, Otani Y, Ido K, Yoshinaga T, Sawada K, Ohwada T. Cui YM, et al. Among authors: otani y. Bioorg Med Chem. 2010 Dec 15;18(24):8642-59. doi: 10.1016/j.bmc.2010.09.072. Epub 2010 Nov 8. Bioorg Med Chem. 2010. PMID: 21067932

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