Needs PW - Search Results

1

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.

Lodi F, Jimenez R, Moreno L, Kroon PA, Needs PW, Hughes DA, Santos-Buelga C, Gonzalez-Paramas A, Cogolludo A, Lopez-Sepulveda R, Duarte J, Perez-Vizcaino F. Lodi F, et al. Among authors: needs pw. Atherosclerosis. 2009 May;204(1):34-9. doi: 10.1016/j.atherosclerosis.2008.08.007. Epub 2008 Aug 14. Atherosclerosis. 2009. PMID: 18801486

2

Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells.

Kern SM, Bennett RN, Needs PW, Mellon FA, Kroon PA, Garcia-Conesa MT. Kern SM, et al. Among authors: needs pw. J Agric Food Chem. 2003 Dec 31;51(27):7884-91. doi: 10.1021/jf030470n. J Agric Food Chem. 2003. PMID: 14690369

3

Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS.

Davis BD, Needs PW, Kroon PA, Brodbelt JS. Davis BD, et al. Among authors: needs pw. J Mass Spectrom. 2006 Jul;41(7):911-20. doi: 10.1002/jms.1050. J Mass Spectrom. 2006. PMID: 16810646

4

Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).

Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M. Williamson G, et al. Drug Metab Dispos. 2007 Aug;35(8):1262-8. doi: 10.1124/dmd.106.014241. Epub 2007 May 3. Drug Metab Dispos. 2007. PMID: 17478601

5

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

Tribolo S, Lodi F, Connor C, Suri S, Wilson VG, Taylor MA, Needs PW, Kroon PA, Hughes DA. Tribolo S, et al. Among authors: needs pw. Atherosclerosis. 2008 Mar;197(1):50-6. doi: 10.1016/j.atherosclerosis.2007.07.040. Epub 2007 Sep 18. Atherosclerosis. 2008. PMID: 17880982

6

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.

Loke WM, Proudfoot JM, Stewart S, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Loke WM, et al. Among authors: needs pw. Biochem Pharmacol. 2008 Mar 1;75(5):1045-53. doi: 10.1016/j.bcp.2007.11.002. Epub 2007 Nov 12. Biochem Pharmacol. 2008. PMID: 18096136

7

Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation.

Loke WM, Proudfoot JM, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Loke WM, et al. Among authors: needs pw. J Agric Food Chem. 2008 May 28;56(10):3609-15. doi: 10.1021/jf8003042. Epub 2008 May 3. J Agric Food Chem. 2008. PMID: 18454540

8

Glucuronidated metabolites of the flavonoid quercetin do not auto-oxidise, do not generate free radicals and do not decrease nitric oxide bioavailability.

Lodi F, Jiménez R, Menendez C, Needs PW, Duarte J, Perez-Vizcaino F. Lodi F, et al. Among authors: needs pw. Planta Med. 2008 Jun;74(7):741-6. doi: 10.1055/s-2008-1074525. Epub 2008 May 16. Planta Med. 2008. PMID: 18484521

9

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.

Winterbone MS, Tribolo S, Needs PW, Kroon PA, Hughes DA. Winterbone MS, et al. Among authors: needs pw. Atherosclerosis. 2009 Feb;202(2):431-8. doi: 10.1016/j.atherosclerosis.2008.04.040. Epub 2008 May 1. Atherosclerosis. 2009. PMID: 18489909

10

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro.

Suri S, Taylor MA, Verity A, Tribolo S, Needs PW, Kroon PA, Hughes DA, Wilson VG. Suri S, et al. Among authors: needs pw. Biochem Pharmacol. 2008 Sep 1;76(5):645-53. doi: 10.1016/j.bcp.2008.06.010. Epub 2008 Jul 1. Biochem Pharmacol. 2008. PMID: 18639531

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