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K1K2Pu, a recombinant t-PA/u-PA chimera with increased thrombolytic potency, consisting of amino acids 1 to 3 and 87 to 274 of human tissue-type plasminogen activator (t-PA) and amino acids 138 to 411 of human single chain urokinase-type plasminogen activator (scu-PA). Purification in centigram quantities and conditioning for use in man.
Collen D, Nelles L, De Cock F, Lemmens G, Van Coetsem T, Demarsin E, Lijnen HR. Collen D, et al. Among authors: demarsin e. Thromb Res. 1992 Feb 1;65(3):421-38. doi: 10.1016/0049-3848(92)90172-7. Thromb Res. 1992. PMID: 1631805
18 results